BioFunctional IntraNeural Electrodes

Introduction

In BioFINE, we will develop flexible intraneural multielectrode arrays, capable of interfacing peripheral nerves, e.g., to transfer input/output signals from bionic limbs. Specifically, we address the challenge of long-term tissue integration and chronic stability by focusing on three aspects of biocompatibility.

Technological Advancements

1. Novel Fabrication Methods
   We develop novel fabrication methods allowing the intraneural interface to be defined at even finer resolution than before.

2. Functionalizations
   We explore functionalizations that will control the tissue response by combined surface-anchored and surface-eluted agents.

3. Structural Biocompatibility
   We address structural biocompatibility on a system level by engineering novel implantable interconnects that reduce tethering forces and improve prospects for high channel count interfaces.

Bioactivity and Healing

Fine-tuned bioactivity will safeguard surrounding neural tissue in the initial stages of healing. Implants of sub-cellular dimensions and tissue-compatible biomechanics will help maintain tissue health in the longer term.

Conclusion

The combined approach will offer optimal conditions to bridge the gap from electrode to neuron and generate a long-term functional peripheral nerve interface. Indeed, each of the three technological advancements would, on their own, have a substantial impact on neurotechnology, reaching far beyond intraneural interfaces.