SubsidieMeestersDistributed and federated cross-modality actuation through advanced nanomaterials and neuromorphic learning
CROSSBRAIN aims to revolutionize brain condition treatment using implantable microbots for real-time, adaptive neuromodulation and sensing in rodent models of Parkinson's Disease and Epilepsy.
Projectdetails
Introduction
A vast number of pathological brain conditions directly involve aberrant electrical activity of the brain. CROSSBRAIN centres its technological revolution on the convergence of novel nanoactuation modalities, bleeding-edge nano-electronics, and miniaturized wireless energy harvesting and communication.
Technological Innovations
Combining extreme edge computing with advanced nanomaterials featuring tailored physical properties, biocompatible coatings, and material modifications to prevent glial scarring, CROSSBRAIN will enable individualized, adaptive, and highly spatiotemporally localized actuation of brain tissue.
Sensing and Modulation
It will leverage sensing electric local field potentials, multiunit neuronal activity, and cross-modal nanomaterial-based modulation (electrical, mechanical, thermal, ionic concentration, optogenetics) of neuronal excitability with on-board intelligence.
CROSSBRAIN Platform
The CROSSBRAIN platform comprises a swarm of wireless, implantable, MRI-compatible microbots for in vivo electrophysiology and cross-modal neuromodulation at the cell- and microcircuit levels, in freely moving rodents.
Stimulation Modalities
CROSSBRAIN delivers a multiplicity of stimulation modalities, involving:
- Electro-mechano-magneto-thermo-optical principles for modulation of nerve cell excitability.
The microbots will feature both sensing and actuation electrodes, engineered with nanomaterials and viral vector coatings.
Implantation and Operation
They will be implanted endovascularly, deliver genetic material upon command, and operate in federation under the networked control and wireless power supply by a tiny central unit, which can be worn like an Internet of Things device.
Closed-Loop System
CROSSBRAIN will deliver autonomous or manual, closed-loop sensing, prediction, and actuation through combining multiple neuromodulation mechanisms, which will act in a synergistic and dynamic manner to optimally shape stimulation according to individual neuronal firing patterns or clinicians' needs.
Case Studies
As case studies, we will explore CROSSBRAIN action in animal models of Parkinson's Disease and Epilepsy.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 4.034.074 |
| Totale projectbegroting | € 4.034.152 |
Tijdlijn
| Startdatum | 1-11-2022 |
| Einddatum | 31-10-2026 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATApenvoerder
- SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE
- PERCUROS BV
- NAMLAB GGMBH
- FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
- ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
- FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
- AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
- INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATORY
- UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
- UNIVERSITY OF GLASGOW
Land(en)
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BRAINSTORM aims to develop a scalable wireless neuromodulation technology using smart magnetic nanomaterials to selectively control deep brain neurons for therapeutic applications in Fragile X syndrome.
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HYBRAIN aims to develop a brain-inspired hybrid architecture combining integrated photonics and unconventional electronics for ultrafast, energy-efficient edge AI inference.
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Developing a mechanogenetic technology using magnetic nanoparticles to non-invasively regulate neural circuits for treating treatment-resistant brain disorders like stroke and epilepsy.
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Multifunctional nano-bio INterfaces wIth deep braiN reGionsMINING aims to develop multifunctional neural endoscopes that simultaneously detect and trigger electrical and chemical signals in vivo, enhancing our understanding of brain dynamics with high resolution. | ERC Consolid... | € 2.992.875 | 2025 | Details |
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Neuromorphic Flexible Electro/chemical Interface for in-Memory Bio-Sensing and Computing.Develop a miniaturized, self-contained biosensing technology using neuromorphic devices for real-time monitoring and classification of neurodegenerative biomarkers in individualized healthcare. | ERC Starting... | € 1.500.000 | 2025 | Details |
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BRAINMASTER aims to develop a scalable, wireless neuromodulation system using magnetic nanodiscs for deep brain therapy and imaging, enhancing cognitive training and treatment for neurological disorders.
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This project aims to develop a portable neuromodulation system using quantum sensors and magnetic stimulation to precisely target brain oscillations for treating mental health disorders.
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