SubsidieMeestersTargeting Epilepsy Ictogenesis Process Through Pannexin-1 Modulation
The project aims to develop a new generation of antiepileptic drugs targeting a novel mechanism to improve treatment for pharmacoresistant epilepsy patients.
Projectdetails
Introduction
Epilepsy, affecting about 1% of the population, comprises a group of neurological disorders characterized by the periodic occurrence of seizures, which disrupt normal brain function.
Current Treatment Challenges
Despite treatment with current antiepileptic drugs, one third of epileptic patients are pharmacoresistant and most patients suffer from side effects. This makes it crucial to develop novel therapies.
Current drugs indeed target channels and receptors involved in normal brain function, which are not specific to the disease.
Project Objective
Our academic work has recently identified a novel and innovative target for epilepsy.
Our project thus aims at bringing to the market a new generation of antiepileptic drugs specifically targeting the disease.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-10-2022 |
| Einddatum | 31-3-2024 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- COLLEGE DE FRANCEpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Targeting epilepsy with phototherapeuticsThis project aims to develop targeted photoactivatable drugs to control focal epilepsy, minimizing side effects and potentially transforming treatment options for intractable cases. | ERC Starting... | € 1.499.375 | 2022 | Details |
Senolytics repurposing in childhood refractory epilepsiesEpiSen aims to develop a precision pharmacological strategy to selectively eliminate mutated cells in Focal Cortical Dysplasia, potentially reducing drug-resistant seizures in children. | ERC Proof of... | € 150.000 | 2023 | Details |
Epilepsy Treatment Using Neuromodulation by Non-Invasive Temporal Interference StimulationThe EMUNITI project aims to develop a non-invasive, personalized brain stimulation device using temporal interference to diagnose and treat epilepsy, enhancing patient care and outcomes. | ERC Consolid... | € 1.996.925 | 2023 | Details |
Minimally invasive and closed-loop ultrasound neuromodulation and recording for the treatment of focal epilepsyThis project aims to develop a minimally invasive, closed-loop ultrasound neuromodulation system for treating refractory epilepsy, optimizing protocols through a comprehensive computational framework. | ERC Starting... | € 1.499.575 | 2025 | Details |
Drug DELIvery to the brain via CHOroid Plexus targetingThis project aims to explore the blood-CSF barrier as a novel route for delivering therapeutics to the brain, potentially enhancing treatment strategies for CNS disorders. | ERC Consolid... | € 1.999.756 | 2024 | Details |
Targeting epilepsy with phototherapeutics
This project aims to develop targeted photoactivatable drugs to control focal epilepsy, minimizing side effects and potentially transforming treatment options for intractable cases.
Senolytics repurposing in childhood refractory epilepsies
EpiSen aims to develop a precision pharmacological strategy to selectively eliminate mutated cells in Focal Cortical Dysplasia, potentially reducing drug-resistant seizures in children.
Epilepsy Treatment Using Neuromodulation by Non-Invasive Temporal Interference Stimulation
The EMUNITI project aims to develop a non-invasive, personalized brain stimulation device using temporal interference to diagnose and treat epilepsy, enhancing patient care and outcomes.
Minimally invasive and closed-loop ultrasound neuromodulation and recording for the treatment of focal epilepsy
This project aims to develop a minimally invasive, closed-loop ultrasound neuromodulation system for treating refractory epilepsy, optimizing protocols through a comprehensive computational framework.
Drug DELIvery to the brain via CHOroid Plexus targeting
This project aims to explore the blood-CSF barrier as a novel route for delivering therapeutics to the brain, potentially enhancing treatment strategies for CNS disorders.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Pannexin 1 – a novel target for pediatric orphan epilepsyPTI5803 is a first-in-class drug that specifically blocks the activated Pannexin 1 channel, effectively reducing seizures in ultra-resistant pediatric epilepsy while preserving cognitive functions. | EIC Accelerator | € 2.499.500 | 2023 | Details |
NOVEL RESUCE-MEDICATION BASED SYSTEM TO PREVENT EPILEPTIC SEIZURESHet project onderzoekt de haalbaarheid van een innovatief apparaat dat epileptische aanvallen voorspelt en voorkomt, ter verbetering van de levenskwaliteit. | Mkb-innovati... | € 20.000 | 2024 | Details |
S4E-platform: Simulaties en Signaaldetectie voor EpilepsieHet project ontwikkelt een AI-platform (S4E) voor het voorspellen van epilepsiesubtypes via hersensimulaties en fNIRS, om diagnostiek en behandeling te verbeteren. | Mkb-innovati... | € 331.450 | 2023 | Details |
SEIZE.SENSEHet project ontwikkelt een innovatief draagbaar apparaat voor realtime epilepsiedetectie, gericht op het verbeteren van patiëntenzorg en veiligheid. | Mkb-innovati... | € 117.810 | 2021 | Details |
Breakthrough Brain Stimulation Device for EpilepsyEASEE is a minimally invasive device for focal cortical stimulation in epilepsy, using a unique quadrupolar electrode system for tailored high-frequency and DC-like stimulation to prevent seizures. | EIC Accelerator | € 2.495.836 | 2023 | Details |
Pannexin 1 – a novel target for pediatric orphan epilepsy
PTI5803 is a first-in-class drug that specifically blocks the activated Pannexin 1 channel, effectively reducing seizures in ultra-resistant pediatric epilepsy while preserving cognitive functions.
NOVEL RESUCE-MEDICATION BASED SYSTEM TO PREVENT EPILEPTIC SEIZURES
Het project onderzoekt de haalbaarheid van een innovatief apparaat dat epileptische aanvallen voorspelt en voorkomt, ter verbetering van de levenskwaliteit.
S4E-platform: Simulaties en Signaaldetectie voor Epilepsie
Het project ontwikkelt een AI-platform (S4E) voor het voorspellen van epilepsiesubtypes via hersensimulaties en fNIRS, om diagnostiek en behandeling te verbeteren.
SEIZE.SENSE
Het project ontwikkelt een innovatief draagbaar apparaat voor realtime epilepsiedetectie, gericht op het verbeteren van patiëntenzorg en veiligheid.
Breakthrough Brain Stimulation Device for Epilepsy
EASEE is a minimally invasive device for focal cortical stimulation in epilepsy, using a unique quadrupolar electrode system for tailored high-frequency and DC-like stimulation to prevent seizures.