SubsidieMeestersEpilepsy Treatment Using Neuromodulation by Non-Invasive Temporal Interference Stimulation
The EMUNITI project aims to develop a non-invasive, personalized brain stimulation device using temporal interference to diagnose and treat epilepsy, enhancing patient care and outcomes.
Projectdetails
Introduction
Epilepsy is a brain disorder characterized by sporadic debilitating seizures and declines in mental health. Available therapies suffer from drawbacks and are not suitable for all patients. The medical needs in epilepsy encapsulate those for clinically managing brain health in general, i.e., the need for precision, personalized, non-systemic, and safer therapies.
Innovative Solutions
Potential innovative solutions are available from advances in technology but will require multidisciplinary teams that bridge between engineering and clinical neurology.
Project Objective
The main objective of the EMUNITI project is to develop a breakthrough, non-invasive, personalized brain stimulation device for epilepsy patients, which serves two purposes:
- As a diagnostic for seizure localization that can guide subsequent surgical resection.
- As a therapy, akin to immunizing the patient against seizures.
The device is based on temporal interference (TI) of electrical signals delivered from positions around the scalp.
Project Leadership
The project will be led by Adam Williamson, who is a former recipient of ERC Starting and Proof-of-Concept grants and has IP for the technology. His lab is at the interface between state-of-the-art engineering and neurology, and is based in a major European centre for clinical research on epilepsy in Marseille, France. His lab has already demonstrated in a pilot study of epilepsy patients that TI can block seizure-provoking brain activity.
Work Packages
The project includes three work packages (WPs):
- WP1 focuses on optimizing TI stimulation at the engineering level and establishing a novel form of TI in multipolar TI (mTI).
- WP2 will evaluate mTI in epilepsy patients, for seizure localization and for therapeutic intervention with the potential to create brain seizure immunity through repeated mTI.
- WP3 administers the project and delivers the main outcome: a clinical prototype with closed-loop stimulation combining mTI and intelligent software.
Anticipated Outcomes
The successful outcome is anticipated to lead to other applications for TI in brain health.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.996.925 |
| Totale projectbegroting | € 1.996.925 |
Tijdlijn
| Startdatum | 1-12-2023 |
| Einddatum | 30-11-2028 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- FAKULTNI NEMOCNICE U SV ANNY V BRNEpenvoerder
Land(en)
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