SubsidieMeestersNature-inspired Cryopreservation Systems using Natural Deep Eutectic Systems
CryoDES aims to commercialize a non-toxic cryoprotectant for cell therapies, enabling safer storage at -20°C and outperforming the toxic DMSO standard, while addressing market needs in life sciences.
Projectdetails
Introduction
Cell therapies are foreseen as the next generation therapeutics for some of the chronic diseases with the highest global economic and social burden. The market for human cell therapies has been estimated to be $8 billion in 2021, with an expected annual growth rate of 26% until 2028.
Importance of Cell Preservation
The key aspect for the success of a cell therapy is the preservation of cells. Currently, cells must be cryopreserved using a cryoprotectant agent (CPA) at -196°C, in a liquid nitrogen tank. The gold standard CPA is a chemical organic compound, dimethyl sulfoxide (DMSO), which is highly toxic. Despite this, it has high success rates and continues to be the industry gold standard CPA.
Development of CryoDES
Inspired by nature, CryoDES was developed. CryoDES is a cryoprotectant agent that is non-toxic and composed of generally regarded as safe components. These systems have proven to be able to replace the gold standard CPA, presenting the same or better performance indicators.
Advantages of CryoDES
One of the major advantages of these systems is the fact that it allows the storage of cells at -20°C, in a conventional freezer, vastly outperforming DMSO.
The CryoDES Team
The CryoDES team is composed of researchers and entrepreneurs who are passionate about science. Together, the CryoDES team has been working on this technology for four years and now envisions bringing it to the next level towards a commercialization strategy.
Objectives of the PoC
To achieve this, in this Proof of Concept (PoC), the team intends to:
- Perform technical feasibility studies of the product.
- Evaluate the commercial value of the product.
- Conduct a market assessment study.
- Draft the plan for commercialization.
Expected Outcomes
Albeit projects and results related to Life Sciences and Biopharmaceuticals require time to become a reality due to the need for the respective pre-clinical and clinical trials, this PoC Action will have as an immediate outcome the creation of a start-up able to commercialize CryoDES for research purposes, for which there is also a large market.
Conclusion
With CryoDES, we will allow cleaner and safer cell therapies for all.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-10-2022 |
| Einddatum | 31-3-2024 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- UNIVERSIDADE NOVA DE LISBOApenvoerder
Land(en)
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Accelerating biofilm Matrix dispersion with Deep Eutectic Solvents
This project aims to develop and commercialize a sustainable NADES-based solution for biofouling mitigation in water treatment, outperforming existing products in safety and effectiveness.
Reliable and scalable procedures for the isolation and loading of extracellular vesicles
LABORIOUS aims to develop innovative methods for isolating and loading therapeutic agents into exosomes, enhancing their clinical application in various diseases while minimizing membrane damage.
Improve the shelf life of perishable goods through stabilization of vitamins
This project aims to enhance the shelf life of vitamins as natural preservatives using deep eutectic systems, improving antioxidant activity and reducing food waste while exploring market viability.
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The project aims to standardize and automate MSC secretome production for pediatric use in treating childhood interstitial lung disease, establishing a scalable and compliant manufacturing process.
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Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
CryoGridDENSsolutions en CryoSol-World ontwikkelen een innovatieve sample carrier voor Cryo-EM om de 3D-structuur van eiwitten beter te visualiseren en de toepassing in de farmaceutische industrie te versnellen. | Mkb-innovati... | € 332.080 | 2023 | Details |
Advanced Sterilization Capability with Low Environmental footprint for Patient Infection Optimized SafetyAURORA's ASCLEPIOS project aims to commercialize a novel non-thermal plasma sterilization technology for medical devices, enhancing patient safety and environmental protection while boosting production capacity. | EIC Accelerator | € 2.499.139 | 2023 | Details |
Cryo HealthDit project ontwikkelt een innovatieve Cryoasauna 2.0 voor veilige, op maat gemaakte cryotherapie, gericht op het verbeteren van de gezondheid van reumapatiënten en integratie in zorgverzekeringen. | Mkb-innovati... | € 188.323 | 2018 | Details |
Vriesconcentratie van eiwithoudende reststromenHet project ontwikkelt een pilotprototype voor energie-efficiënte ontwatering van eiwitten uit organische nevenstromen, met een verwachte energiebesparing van 25% tot 50%. | Demonstratie... | € 758.775 | 2020 | Details |
ECOFLOW & ECOSOL Hightech disposible donororgaan preservatiemethodeHet project ontwikkelt een innovatief preservatiesysteem voor donororganen dat pulserend zuurstof biedt, waardoor organen langer behouden blijven en het wereldwijde tekort aan transplantaties aanpakt. | Mkb-innovati... | € 198.597 | 2015 | Details |
CryoGrid
DENSsolutions en CryoSol-World ontwikkelen een innovatieve sample carrier voor Cryo-EM om de 3D-structuur van eiwitten beter te visualiseren en de toepassing in de farmaceutische industrie te versnellen.
Advanced Sterilization Capability with Low Environmental footprint for Patient Infection Optimized Safety
AURORA's ASCLEPIOS project aims to commercialize a novel non-thermal plasma sterilization technology for medical devices, enhancing patient safety and environmental protection while boosting production capacity.
Cryo Health
Dit project ontwikkelt een innovatieve Cryoasauna 2.0 voor veilige, op maat gemaakte cryotherapie, gericht op het verbeteren van de gezondheid van reumapatiënten en integratie in zorgverzekeringen.
Vriesconcentratie van eiwithoudende reststromen
Het project ontwikkelt een pilotprototype voor energie-efficiënte ontwatering van eiwitten uit organische nevenstromen, met een verwachte energiebesparing van 25% tot 50%.
ECOFLOW & ECOSOL Hightech disposible donororgaan preservatiemethode
Het project ontwikkelt een innovatief preservatiesysteem voor donororganen dat pulserend zuurstof biedt, waardoor organen langer behouden blijven en het wereldwijde tekort aan transplantaties aanpakt.