SubsidieMeestersTargeting peripheral nerves: a method for therapeutic modulation of inflammatory disease with non-invasive temporal interference
The project aims to develop a non-invasive, patch-based nerve stimulator using Temporal Interference to precisely target inflammation-regulating nerves, enhancing treatment for inflammatory diseases.
Projectdetails
Introduction
Excessive inflammation underlies the development of inflammatory diseases, e.g. Rheumatoid arthritis, Crohn's Disease, inflammatory bowel disease, and cardiovascular disease - the most common cause of death in the world. Human physiology is controlled by defined molecular mechanisms, commonly controlled by specific target nerves and their associated reflexes which optimize function, for example, molecular mechanisms regulating inflammation.
Bioelectronic Medicine
Harnessing the power of the inherent nerve reflexes which are evolutionarily adapted to regulate specific molecular mechanisms holds promise to overcome many of the drawbacks intrinsic to current drug therapies. This approach, designated bioelectronic medicine, presents a radically improved way to both treat and better understand disease with increased adaptability and precision.
Role of the Vagus Nerve
The vagus nerve, as shown by the team in this project and other groups, plays a key role in regulating key pro-inflammatory cytokines, pro-resolving mediators, and controls inflammation. However, specific targeting of the vagus nerve has required neurosurgical implantation of a pacemaker-like stimulator device with a control unit, a connecting cable, and an electrode implanted at depth.
Limitations of Current Methods
The requirement for highly specialized surgery significantly limits the usefulness and possibilities for implementation of nerve stimulation in the treatment of inflammation. Surgery and device implantation also carry risks for:
- Permanent tissue damage
- Local inflammation
- Infection
- Other potentially serious complications
Project Goals
TREATMENT will generate a precise, non-invasive nerve stimulator that uses Temporal Interference in an ultra-thin form factor (enabling patch-based applications) that will:
- Target one nerve of interest and avoid off-target stimulation
- Avoid surgery
- Simplify effective use
- Enable bioelectronic medicine
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-4-2023 |
| Einddatum | 30-9-2024 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- FAKULTNI NEMOCNICE U SV ANNY V BRNEpenvoerder
Land(en)
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Vergelijkbare projecten uit andere regelingen
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Network Synergies in Tissue Homeostasis and Stromal Prevention of Inflammatory Disease.This project aims to uncover the mechanisms of tissue homeostasis and stromal biology to prevent inflammation onset, using advanced bioimaging and computational techniques for therapeutic advancements. | ERC STG | € 1.499.514 | 2022 | Details |
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This project aims to uncover the mechanisms of tissue homeostasis and stromal biology to prevent inflammation onset, using advanced bioimaging and computational techniques for therapeutic advancements.
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This project aims to restore vagal tone in IBS patients through transcutaneous electrical vagus nerve stimulation, potentially transforming treatment by identifying a neurosignature for personalized therapy.
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