SubsidieMeestersPERSONALIZED NON-INVASIVE NEUROMODULATION IN PAIN
PersoNINpain aims to personalize chronic pain treatment by using brain connectivity metrics to optimize non-invasive neuromodulation techniques like rTMS for individual patients.
Projectdetails
Introduction
Chronic pain (CP) is the most prevalent disease worldwide and is a major societal challenge. Different people with the same pain condition experience it differently. Irrespective of its origin, CP is maintained by altered connectivity between brain regions, which can be modulated towards normality by effective treatment.
Current Treatment Landscape
Several pharmacological and non-pharmacological strategies exist to treat pain, but 40% of individuals remain symptomatic despite treatment. Current treatment for CP is not personalized, being delivered in a standardized regimen irrespective of patients' brain network status, which partially justifies therapeutic refractoriness.
Non-Invasive Neuromodulation Techniques
Non-invasive neuromodulation (NIN) techniques such as repetitive transcranial magnetic stimulation (rTMS) are used in the long-term treatment of a wide spectrum of brain disorders as an alternative to medication-exclusive regimens. NIN can modulate altered connectivity towards normal patterns and relieve symptoms with minimal side effects. However, to date, its application has also been non-individualized, which equally impacts its therapeutic potential.
Proposed Study
I propose a comprehensive package of studies using measurements of local-to-global brain connectivity to individualize pain treatment. By probing different brain regions using single pulse-TMS and reading the subsequent brain oscillatory responses by electroencephalography, one can:
- Screen potential treatment targets.
- Classify them according to their efficacy potential in a pre-treatment session.
This will allow the identification of the best cortical region to be used as a treatment target by rTMS, thus providing a personalized choice of the ideal entry point to drive brain global connectivity towards normalized patterns for each patient.
Conclusion
With the development of local-to-general brain connectivity metrics guiding NIN treatment, PersoNINpain will provide an innovative and groundbreaking approach to transform the treatment of the world’s most impactful health condition - chronic pain.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.618.278 |
| Totale projectbegroting | € 1.618.278 |
Tijdlijn
| Startdatum | 1-8-2023 |
| Einddatum | 31-7-2028 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- AALBORG UNIVERSITETpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
MANUNKIND: Determinants and Dynamics of Collaborative ExploitationThis project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery. | ERC STG | € 1.497.749 | 2022 | Details |
Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressureThe UnderPressure project aims to investigate how mechanical constraints from 3D crowding affect cell proliferation and signaling in various organisms, with potential applications in reducing cancer chemoresistance. | ERC STG | € 1.498.280 | 2022 | Details |
Uncovering the mechanisms of action of an antiviral bacteriumThis project aims to uncover the mechanisms behind Wolbachia's antiviral protection in insects and develop tools for studying symbiont gene function. | ERC STG | € 1.500.000 | 2023 | Details |
The Ethics of Loneliness and SociabilityThis project aims to develop a normative theory of loneliness by analyzing ethical responsibilities of individuals and societies to prevent and alleviate loneliness, establishing a new philosophical sub-field. | ERC STG | € 1.025.860 | 2023 | Details |
MANUNKIND: Determinants and Dynamics of Collaborative Exploitation
This project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery.
Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressure
The UnderPressure project aims to investigate how mechanical constraints from 3D crowding affect cell proliferation and signaling in various organisms, with potential applications in reducing cancer chemoresistance.
Uncovering the mechanisms of action of an antiviral bacterium
This project aims to uncover the mechanisms behind Wolbachia's antiviral protection in insects and develop tools for studying symbiont gene function.
The Ethics of Loneliness and Sociability
This project aims to develop a normative theory of loneliness by analyzing ethical responsibilities of individuals and societies to prevent and alleviate loneliness, establishing a new philosophical sub-field.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Descending control of painDescendPain aims to classify RVM neuron types and uncover how brain modulation of pain varies with affective states, potentially transforming pain treatment strategies. | ERC ADG | € 2.500.000 | 2023 | Details |
Targeting peripheral nerves: a method for therapeutic modulation of inflammatory disease with non-invasive temporal interferenceThe project aims to develop a non-invasive, patch-based nerve stimulator using Temporal Interference to precisely target inflammation-regulating nerves, enhancing treatment for inflammatory diseases. | ERC POC | € 150.000 | 2023 | Details |
Chronic PAIN eradiCAtion by taRgeting Schwann cEllsPAIN-CARE aims to develop Schwann cell selective analgesic drugs to effectively treat chronic pain with fewer side effects than current NSAIDs and opioids, advancing towards pre-commercialization. | ERC POC | € 150.000 | 2023 | Details |
A mechanism-based approach to the prevention of chronic pain and its comorbid mental disordersThis project aims to transform chronic pain treatment by identifying transdiagnostic mechanisms and developing digital and virtual reality interventions to prevent chronicity and associated mental disorders. | ERC ADG | € 2.424.481 | 2024 | Details |
Descending control of pain
DescendPain aims to classify RVM neuron types and uncover how brain modulation of pain varies with affective states, potentially transforming pain treatment strategies.
Targeting peripheral nerves: a method for therapeutic modulation of inflammatory disease with non-invasive temporal interference
The project aims to develop a non-invasive, patch-based nerve stimulator using Temporal Interference to precisely target inflammation-regulating nerves, enhancing treatment for inflammatory diseases.
Chronic PAIN eradiCAtion by taRgeting Schwann cElls
PAIN-CARE aims to develop Schwann cell selective analgesic drugs to effectively treat chronic pain with fewer side effects than current NSAIDs and opioids, advancing towards pre-commercialization.
A mechanism-based approach to the prevention of chronic pain and its comorbid mental disorders
This project aims to transform chronic pain treatment by identifying transdiagnostic mechanisms and developing digital and virtual reality interventions to prevent chronicity and associated mental disorders.