Single-fibre based holographic endoscope for observations of stroke in deep brain structure

Introduction

The origin project LIFEGATE introduced the prospect of multimode fibre based holographic endoscope as a unique tool for high-resolution in-vivo imaging of structures residing deep inside the brain of animal models. It harnesses the power of controlled light transport through hair-thin MMFs to image and measure brain functions at single cell and sub-cellular level in virtually any brain structure, at unlimited depth and in uniquely atraumatic manner, thereby unlocking a variety of opportunities when answering urgent bio-medical questions.

Project Goals

The proposed ERC-PoC project StrokeGATE aims to utilise achievements of the origin project to introduce a novel, complete technological platform for investigating the impact of deep-brain stroke in living animal models.

Modifications and Applications

1. The geometry of the most advanced holographic endoscope currently built will be modified to allow induction of stroke of controlled magnitude.
2. This represents a powerful extension of the instrument's applicability from the perspective of the users in neuroscience.
3. The already available imaging capacity of the instrument will facilitate its navigation into the desired brain structure.

Monitoring and Analysis

Once the stroke is induced, the project will focus on monitoring changes to:

• Structural connectivity of the neurones within a circuit
• Development / suppression of signalling activity

Commercialisation Pathway

LIFEGATE has already established a solid pathway to commercialisation through a start-up endeavour. Although intellectual property is expected to be generated during the execution of StrokeGATE, its main translational value lies in demonstrating the utility of MMF endoscopes across the relevant community of researchers who by now had only limited chances to fully appreciate the potential of such radically new and disruptive technological arrival.

Conclusion

Successful accomplishment of StrokeGATE will unlock the exploitability of holographic endoscopy across a wider topical range of biomedical research and reduce its translational barriers.