SubsidieMeestersMinimally Invasive Neuromodulation Implant and implantation procedure based on ground-breaking GRAPHene technology for treating brain disorders
The MINIGRAPH project aims to revolutionize neuromodulation therapy for brain diseases by developing minimally invasive, personalized brain implants with closed-loop capabilities and high-resolution graphene microelectrodes.
Projectdetails
Introduction
Neurostimulation therapies hold the promise to treat brain diseases refractory to pharmacological treatment. However, these therapies are not fully adopted due to important technological and clinical challenges, such as:
- Highly invasive implantation
- Multiple side effects due to off-target stimulation
- Low signal resolution
- Lack of personalized therapies
Project Overview
The MINIGRAPH project aims to develop a ground-breaking neuromodulation therapy that addresses current needs of the field. We will develop and validate a new generation of brain implants with closed-loop neuromodulation capabilities, enabled by:
- Skull implanted flexible electronics unit
- Miniature and high-density arrays of graphene microelectrodes
Our implant will feature high miniaturization, large spatial resolution, and optimal biocompatibility with brain tissue. The closed-loop capabilities will enable the development of personalized and adaptive therapies depending on patients’ needs.
Minimally Invasive Procedure
In addition, we will also develop and validate a minimally invasive implantation procedure with:
- High precision implantation
- Low invasiveness through a single small skull incision
Impact and Consortium
The MINIGRAPH project outcomes will truly revolutionize the way we treat neurological and neuropsychiatric diseases in the near future. To achieve our ambitious objectives, we have put together an interdisciplinary consortium formed by high-renowned research centers and a high-promising SME, with all the expertise and resources needed to complete the project within time and budget.
Alignment with Pathfinder Challenge
Our project addresses the objectives of the “Tools to measure and stimulate activity in brain tissue” pathfinder challenge, as it provides:
- Miniature and minimally invasive brain implants
- Closed-loop neuromodulation therapy for personalized medicine
- Biocompatible ultra-thin and flexible neuroelectrodes
- Minimized power consumption solution
All together, we believe the MINIGRAPH project will be a unique addition to the challenge portfolio.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 4.428.402 |
| Totale projectbegroting | € 4.428.402 |
Tijdlijn
| Startdatum | 1-10-2022 |
| Einddatum | 30-6-2026 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIApenvoerder
- INBRAIN NEUROELECTRONICS SL
- INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
- FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
- ACADEMISCH ZIEKENHUIS LEIDEN
- UNIVERZITA PALACKEHO V OLOMOUCI
- EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
- Nanoflex Robotics A.G
Land(en)
Vergelijkbare projecten binnen EIC Pathfinder
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
MagnetoElectric and Ultrasonic Technology for Advanced BRAIN modulationMETA-BRAIN aims to develop non-invasive, precise control of brain activity using magnetoelectric nanoarchitectures and ultrasonic technologies, enhancing treatment for neurological disorders. | EIC Pathfinder | € 2.987.655 | 2024 | Details |
A synaptic mechanogenetic technology to repair brain connectivityDeveloping a mechanogenetic technology using magnetic nanoparticles to non-invasively regulate neural circuits for treating treatment-resistant brain disorders like stroke and epilepsy. | EIC Pathfinder | € 3.543.967 | 2023 | Details |
AEGEUS - A Novel EEG Ultrasound Device for Functional Brain Imaging and NeurostimulationDevelop a novel wearable device combining ultrasound imaging and EEG for enhanced diagnosis and treatment of neurological disorders, aiming for improved patient outcomes and research advancements. | EIC Pathfinder | € 2.998.988 | 2023 | Details |
Wireless deep BRAIN STimulation thrOugh engineeRed Multifunctinal nanomaterialsBRAINSTORM aims to develop a scalable wireless neuromodulation technology using smart magnetic nanomaterials to selectively control deep brain neurons for therapeutic applications in Fragile X syndrome. | EIC Pathfinder | € 3.083.850 | 2023 | Details |
Revolutionary high-resolution human 3D brain organoid platform integrating AI-based analyticsThe 3D-BrAIn project aims to develop a personalized bio-digital twin of the human brain using advanced organoid cultures and machine learning to enhance precision medicine for CNS disorders. | EIC Pathfinder | € 1.998.347 | 2023 | Details |
MagnetoElectric and Ultrasonic Technology for Advanced BRAIN modulation
META-BRAIN aims to develop non-invasive, precise control of brain activity using magnetoelectric nanoarchitectures and ultrasonic technologies, enhancing treatment for neurological disorders.
A synaptic mechanogenetic technology to repair brain connectivity
Developing a mechanogenetic technology using magnetic nanoparticles to non-invasively regulate neural circuits for treating treatment-resistant brain disorders like stroke and epilepsy.
AEGEUS - A Novel EEG Ultrasound Device for Functional Brain Imaging and Neurostimulation
Develop a novel wearable device combining ultrasound imaging and EEG for enhanced diagnosis and treatment of neurological disorders, aiming for improved patient outcomes and research advancements.
Wireless deep BRAIN STimulation thrOugh engineeRed Multifunctinal nanomaterials
BRAINSTORM aims to develop a scalable wireless neuromodulation technology using smart magnetic nanomaterials to selectively control deep brain neurons for therapeutic applications in Fragile X syndrome.
Revolutionary high-resolution human 3D brain organoid platform integrating AI-based analytics
The 3D-BrAIn project aims to develop a personalized bio-digital twin of the human brain using advanced organoid cultures and machine learning to enhance precision medicine for CNS disorders.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Engineering Graphene for developing Neural Interfaces to revolutionize how we treat neurological diseasesINBRAIN Neuroelectronics is developing AI-powered graphene-based neural implants to enhance resolution and specificity in neuroelectronic therapies for refractory neurological disorders. | EIC Accelerator | € 2.493.750 | 2023 | Details |
Injectable nanoelectrodes for wireless and minimally invasive neural stimulationDeveloping minimally invasive, nanoscale, wireless neuroelectrodes for targeted neural stimulation to improve treatment accessibility for neurological impairments. | ERC Starting... | € 1.499.725 | 2023 | Details |
Multifunctional nano-bio INterfaces wIth deep braiN reGionsMINING aims to develop multifunctional neural endoscopes that simultaneously detect and trigger electrical and chemical signals in vivo, enhancing our understanding of brain dynamics with high resolution. | ERC Consolid... | € 2.992.875 | 2025 | Details |
Graphene Transistors for High-Density Brain-Computer InterfacesThe project develops graphene-based transistors for high-resolution brain mapping and monitoring, aiming to enhance brain-computer interfaces with fewer wires and better integration. | EIC Transition | € 2.495.000 | 2023 | Details |
Minimally invasive endoscopes for neuronal activity monImaging-assisted single-cell specific activity monitoring and optogenetic stimulation of deep brain structures in motile and awaken animal modelsWOKEGATE aims to enhance minimally invasive endoscopes for real-time monitoring of neuronal activity in awake animals, facilitating advanced neuroscience research and commercial applications. | ERC Proof of... | € 150.000 | 2022 | Details |
Engineering Graphene for developing Neural Interfaces to revolutionize how we treat neurological diseases
INBRAIN Neuroelectronics is developing AI-powered graphene-based neural implants to enhance resolution and specificity in neuroelectronic therapies for refractory neurological disorders.
Injectable nanoelectrodes for wireless and minimally invasive neural stimulation
Developing minimally invasive, nanoscale, wireless neuroelectrodes for targeted neural stimulation to improve treatment accessibility for neurological impairments.
Multifunctional nano-bio INterfaces wIth deep braiN reGions
MINING aims to develop multifunctional neural endoscopes that simultaneously detect and trigger electrical and chemical signals in vivo, enhancing our understanding of brain dynamics with high resolution.
Graphene Transistors for High-Density Brain-Computer Interfaces
The project develops graphene-based transistors for high-resolution brain mapping and monitoring, aiming to enhance brain-computer interfaces with fewer wires and better integration.
Minimally invasive endoscopes for neuronal activity monImaging-assisted single-cell specific activity monitoring and optogenetic stimulation of deep brain structures in motile and awaken animal models
WOKEGATE aims to enhance minimally invasive endoscopes for real-time monitoring of neuronal activity in awake animals, facilitating advanced neuroscience research and commercial applications.