SubsidieMeestersMonitoring of stroke patients with 3D ultrasound localization microscopy
The ERC POC StrokeMonitor project aims to validate a portable super-resolution ultrasound device for monitoring delayed cerebral ischemia in stroke patients, enhancing neuroimaging accessibility and accuracy.
Projectdetails
Introduction
The ERC Cog ResolveStroke has led to the development of a new imaging device, based on super-resolution ultrasound, which can assess ischemic and hemorrhagic stroke through the observation of the smallest blood vessels that are invisible to other medical imaging modalities.
StrokeScanner Development
This StrokeScanner is currently being demonstrated in large models before being applied to human studies at the end of the project. Its remarkable results have led to the creation of a startup (Resolve Stroke) which conceives a portable and 3D super-resolution ultrasound scanner to improve access to neuroimaging for stroke patients.
Need for Monitoring
In particular, there is a dire need to monitor the cerebral blood flows at the patient’s bedside after the acute phase. Delayed cerebral ischemia arises in a third of all patients suffering from subarachnoid hemorrhage (about 800,000 cases worldwide per year).
Limitations of Current Methods
Transcranial Doppler is used to explore large vessel circulation but is blind to fine vascular alterations. We believe that ultrasound super-resolution could bring a new diagnostic tool to help patients and physicians, with a resolution and sensitivity comparable to CT Angiography on a device smaller than carry-on luggage.
Goals of ERC POC StrokeMonitor
The goal of the ERC POC StrokeMonitor is to establish the performance and usefulness of this approach to monitor Delayed Cerebral Ischemia. The demonstration will be performed both in models and in human patients.
- A model of subarachnoid hemorrhage will be imaged over several days to determine the dynamics of the microcirculation alterations.
- A clinically validated StrokeScanner will then be tested on SAH patients at CHU de Caen to identify biomarkers of delayed cerebral ischemia in hemorrhagic stroke patients.
Conclusion
Through this ERC POC StrokeMonitor, we will extend the applicability of the StrokeScanner in neurovascular units in hospitals to help patients’ follow-up and generate stronger proof of ultrasound super-resolution for neuroimaging.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-2-2023 |
| Einddatum | 31-7-2024 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRSpenvoerder
- RESOLVE STROKE SAS
Land(en)
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Vergelijkbare projecten uit andere regelingen
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