SubsidieMeestersDeep Brain Neuromodulation using Temporal Interference Magnetic Stimulation
Develop a non-invasive tool using temporal interference magnetic stimulation for precise modulation of neural activity in the brain, aiming to improve treatment options for brain disorders.
Projectdetails
Introduction
Five out of ten diseases leading to long-term disability are related to the brain, including stroke, depression, or dementia. Despite tremendous progress in neurotechnology, there is still no effective treatment option available for many brain-related disorders.
Current Limitations
A very promising approach to treat brain disorders uses transcranial electric or magnetic stimulation (TES/TMS) to directly influence brain activity related to specific symptoms. However, these methods are limited in their:
- Spatial resolution
- Specificity
- Ability to reach deep brain areas
Project Aim
The aim of the proposed project is to develop a technical and experimental proof-of-concept for a new non-invasive tool that allows for millimeter- and millisecond-precise modulation of neural activity in superficial and deep areas of the human brain.
Methodology
Capitalizing on temporal interference effects, the device will apply high carrier frequency magnetic fields through a pair of coils. By modulating their relative phase, the combined fields will induce a locally amplitude-modulated electric field in the brain.
Mechanism of Action
As neural tissue is insensitive to unmodulated high-frequency fields (>1kHz), but responds to low-frequency amplitude-modulated fields, only brain regions will be stimulated where the combined field is amplitude-modulated.
Goals
Building on the resulting versatility of stimulation frequencies and waveforms, we aim to provide proof for:
- Cell-type specificity of such temporal interference magnetic stimulation (TIMS).
- The feasibility of targeting neural activity at millisecond-to-millisecond precision.
Expected Outcomes
The availability of such a device offering high spatial resolution, depth selectivity, steerability, as well as closed-loop compatibility and cell-type specificity would mark a major breakthrough for clinical neuroscience.
Collaboration
Together with two partners from industry and a partner for technology transfer, we strive for fast translation of expected research results into innovative products.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-11-2022 |
| Einddatum | 30-4-2024 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- CHARITE - UNIVERSITAETSMEDIZIN BERLINpenvoerder
Land(en)
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