SubsidieMeestersClosed-loop Individualized image-guided Transcranial Ultrasonic Stimulation
The project aims to develop a neuronavigated transcranial ultrasound stimulation (TUS) system for precise, non-invasive modulation of deep brain structures to treat neurological and psychiatric disorders.
Projectdetails
Introduction
We are joining forces across Europe to advance a new non-invasive technology – transcranial ultrasound stimulation (TUS) – to reversibly modulate brain regions with exquisite millimetre precision, even deep in the brain. As such, we aim to establish an urgently needed novel treatment option for neurological and psychiatric diseases.
Technology Overview
TUS combines the precision and reach of invasive deep brain stimulation, required to directly target clinically relevant structures, with the non-invasive and low-cost nature of transcranial electromagnetic techniques that are inherently limited in focus and depth.
Challenges
The main roadblock to widespread adoption of TUS in neuroscientific and clinical applications is the difficulty of steering the small ultrasound focus onto the intended target and reaching the desired intensity, with no empirical validation of targeting success currently available.
Development Plan
We will develop a neuronavigated TUS-MRI system with advanced magnetic resonance imaging (MRI)-guided application planning and closed-loop application control to enable safe, individualized, and effective high-precision TUS in humans.
Potential Impact
As such, we will unlock the full potential of TUS to non-invasively modulate deep brain structures with unprecedented spatial precision in the millimetre range.
Final Prototype
The final prototype will be a fully functional device that integrates:
- Novel MR-compatible 256-element TUS-transducers (for advanced 3D-steering of the TUS focus)
- A custom-tailored 32-channel MR-receiver coil (for accelerated imaging with maximal sensitivity)
- Closed-loop target validation using MR-acoustic radiation force imaging (MR-ARFI)
This novel device with its unique features will enable for the first time the personalized non-invasive high-precision stimulation of cortical and subcortical targets in the human brain.
Conclusion
It will be a game changer for both neuroscientific research and clinical application in neurological and psychiatric diseases with the potential to benefit millions of patients.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 3.799.402 |
| Totale projectbegroting | € 3.799.402 |
Tijdlijn
| Startdatum | 1-10-2022 |
| Einddatum | 30-9-2026 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- MEDIZINISCHE UNIVERSITAET WIENpenvoerder
- UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
- REGION HOVEDSTADEN
- VYSOKE UCENI TECHNICKE V BRNE
- LOCALITE GMBH
- FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
- STICHTING RADBOUD UNIVERSITEIT
- UNIVERSITY COLLEGE LONDON
Land(en)
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Focused Ultrasound Personalized Therapy for the Treatment of Depression (UPSIDE)
The UPSIDE project aims to develop a minimally invasive hybrid neurotechnology for targeted brain stimulation and biomarker monitoring to enhance treatment for Treatment-Resistant Depression.
MagnetoElectric and Ultrasonic Technology for Advanced BRAIN modulation
META-BRAIN aims to develop non-invasive, precise control of brain activity using magnetoelectric nanoarchitectures and ultrasonic technologies, enhancing treatment for neurological disorders.
AEGEUS - A Novel EEG Ultrasound Device for Functional Brain Imaging and Neurostimulation
Develop a novel wearable device combining ultrasound imaging and EEG for enhanced diagnosis and treatment of neurological disorders, aiming for improved patient outcomes and research advancements.
Wireless deep BRAIN STimulation thrOugh engineeRed Multifunctinal nanomaterials
BRAINSTORM aims to develop a scalable wireless neuromodulation technology using smart magnetic nanomaterials to selectively control deep brain neurons for therapeutic applications in Fragile X syndrome.
Transforming brain surgery by advancing functional-guided neuronavigational imaging
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Develop a non-invasive tool using temporal interference magnetic stimulation for precise modulation of neural activity in the brain, aiming to improve treatment options for brain disorders.
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