SubsidieMeestersAntibiotics of the future: are they prone to bacterial resistance?
This project aims to develop a forecasting framework for the long-term effectiveness of new antibiotics by studying bacterial resistance evolution and its implications for future antibiotic design and use.
Projectdetails
Introduction
Although several new antibiotic candidates are in the clinical pipeline, the future evolution of resistance in bacteria may render them ineffective. This project aims to develop a framework for forecasting the long-term effectiveness of new antibiotic candidates.
Objectives
For this purpose, we will decipher the general principles shaping bacterial resistance to a wide range of antibiotic candidates currently in development. Using recently developed methods in our laboratory, we will study resistance evolution in bacterial ESKAPE pathogens at unprecedented resolution and address four specific aims:
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Shared Features of Antibiotics
We explore the shared features of antibiotics with limited susceptibility to resistance. -
Species-Specific Differences
We systematically map species-specific differences in resistance evolution with implications on narrow-spectrum antibacterial therapies that could remain effective. -
Clinical Risks Associated with Resistance
We assess the clinical risks associated with resistance by studying the global biogeography and habitat-specificity of resistant bacteria. -
Links Between Resistance Evolution and Virulence
Finally, we systematically explore the potential links between resistance evolution and increased bacterial virulence.
Expected Outcomes
The outcomes will provide guidelines for future antibiotic use, aid in genomic surveillance of resistance genes, and facilitate the design of antibiotics with reduced susceptibility to resistance.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 3.479.716 |
| Totale projectbegroting | € 3.479.716 |
Tijdlijn
| Startdatum | 1-7-2024 |
| Einddatum | 30-6-2029 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- HUN-REN SZEGEDI BIOLOGIAI KUTATOKOZPONTpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
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|---|---|---|---|---|
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MANUNKIND: Determinants and Dynamics of Collaborative Exploitation
This project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery.
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This project aims to uncover the mechanisms behind Wolbachia's antiviral protection in insects and develop tools for studying symbiont gene function.
The Ethics of Loneliness and Sociability
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Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Exploiting plasmid–bacteria interactions to fight the evolution of antimicrobial resistancePLAS-FIGHTER aims to develop innovative strategies against plasmid-mediated antimicrobial resistance by exploring plasmid-induced physiological effects in bacteria using advanced screening and ecological models. | ERC COG | € 1.999.573 | 2024 | Details |
Deep learning analysis of imaging and metabolomic data to accelerate antibiotic discovery against antimicrobial resistanceAI4AMR aims to revolutionize antibiotic discovery by using advanced AI and multi-dimensional data analysis to identify novel antibiotics and their mechanisms of action against antimicrobial resistance. | ERC SyG | € 10.968.734 | 2025 | Details |
InnomABsImmunoPrecise Antibodies (IPA) onderzoekt de haalbaarheid van het ontwikkelen van menselijke eiwitten (biologicals) als alternatief voor antibiotica om antimicrobiële resistentie te bestrijden. | MIT Haalbaarheid | € 14.888 | 2023 | Details |
Behandeling van antibioticaresistente S. aureus en preventie van verdere antibioticaresistentieHet project onderzoekt de haalbaarheid van een op antilichamen gebaseerd product voor de behandeling van S. aureus-infecties, gericht op genezing en het voorkomen van antibioticaresistentie. | MIT Haalbaarheid | € 20.000 | 2021 | Details |
Exploiting plasmid–bacteria interactions to fight the evolution of antimicrobial resistance
PLAS-FIGHTER aims to develop innovative strategies against plasmid-mediated antimicrobial resistance by exploring plasmid-induced physiological effects in bacteria using advanced screening and ecological models.
Deep learning analysis of imaging and metabolomic data to accelerate antibiotic discovery against antimicrobial resistance
AI4AMR aims to revolutionize antibiotic discovery by using advanced AI and multi-dimensional data analysis to identify novel antibiotics and their mechanisms of action against antimicrobial resistance.
InnomABs
ImmunoPrecise Antibodies (IPA) onderzoekt de haalbaarheid van het ontwikkelen van menselijke eiwitten (biologicals) als alternatief voor antibiotica om antimicrobiële resistentie te bestrijden.
Behandeling van antibioticaresistente S. aureus en preventie van verdere antibioticaresistentie
Het project onderzoekt de haalbaarheid van een op antilichamen gebaseerd product voor de behandeling van S. aureus-infecties, gericht op genezing en het voorkomen van antibioticaresistentie.