SubsidieMeestersPRInted Symbiotic Materials as a dynamic platform for Living Tissues production
PRISM-LT aims to develop a flexible bioprinting platform using hybrid living materials to enhance stem cell differentiation with engineered helper cells for biomedical and food applications.
Projectdetails
Introduction
The PRISM-LT aims at creating a flexible platform for next generation living tissue manufacturing based on Hybrid Living Materials.
Bio-Ink Design
We plan to design a novel bio-ink where stem cells are integrated in a support matrix enriched with engineered helper cells (either bacteria or yeasts, depending on the application and requirements).
Bioprinting Process
Tuning the operational parameters of the bioprinting process, we will cast down the material controlling the mechanical properties of each voxel. This will allow us to achieve a 3D patterned structure where stem cells are locally induced to initiate their differentiation towards different lineages.
Stem Cell and Helper Cell Interaction
As far as stem cells proliferate, the helpers remain in a quiescent state. However, when the stem cells get stimulated by the local (printed) mechanics and enter a differentiation pathway, they start secreting a pool of lineage-specific metabolites.
The helper cells are designed to:
- Sense these early markers of differentiation.
- Respond by producing in-situ the corresponding growth factors, providing the relevant chemical guidance.
Helper cells within the platform amplify the initial lineage commitment in each area and dynamically sustain differentiation on a longer term.
Project Implementation
During the project, we will implement this strategy and develop two independent symbiotic materials, targeting biomedical and food applications, respectively.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.805.403 |
| Totale projectbegroting | € 2.805.403 |
Tijdlijn
| Startdatum | 1-11-2022 |
| Einddatum | 31-10-2027 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- IN SRL IMPRESA SOCIALEpenvoerder
- CHALMERS TEKNISKA HOGSKOLA AB
- STICHTING RADBOUD UNIVERSITEIT
- BICO GROUP AB
- CELLINK BIOPRINTING AB
- UNIVERSIDADE DE AVEIRO
- UNIVERSITY OF GLASGOW
Land(en)
Vergelijkbare projecten binnen EIC Pathfinder
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
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High-throughput ultrasound-based volumetric 3D printing for tissue engineeringSONOCRAFT aims to revolutionize myocardial cell construct bioprinting by combining rapid volumetric printing with ultrasonic manipulation to create functional cardiac models for drug testing and disease research. | EIC Pathfinder | € 2.999.625 | 2025 | Details |
building vascular networks and Blood-Brain-Barriers through a Biomimetic manufacturing Technology for the fabrication of Human tissues and ORgansTHOR aims to revolutionize tissue engineering by creating patient-specific, fully functional human tissues using bioinspired mini-robots, eliminating the need for organ transplants. | EIC Pathfinder | € 3.994.150 | 2023 | Details |
Next Generation 3D Tissue Models: Bio-Hybrid Hierarchical Organoid-Synthetic Tissues (Bio-HhOST) Comprised of Live and Artificial Cells.
Bio-HhOST aims to create bio-hybrid materials with living and artificial cells for dynamic communication, enhancing tissue modeling and reducing animal use in drug research.
Living Therapeutic and Regenerative Materials with Specialised Advanced Layers
Developing skin-inspired engineered living materials with sensing and regenerative functions for therapeutic and protective applications through multicellular consortia and genetic control.
High-throughput ultrasound-based volumetric 3D printing for tissue engineering
SONOCRAFT aims to revolutionize myocardial cell construct bioprinting by combining rapid volumetric printing with ultrasonic manipulation to create functional cardiac models for drug testing and disease research.
building vascular networks and Blood-Brain-Barriers through a Biomimetic manufacturing Technology for the fabrication of Human tissues and ORgans
THOR aims to revolutionize tissue engineering by creating patient-specific, fully functional human tissues using bioinspired mini-robots, eliminating the need for organ transplants.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
A novel support material for 3D bioprinting and post-printing tissue growth: Print and GrowThe "Print and Grow" project aims to enhance 3D bioprinting stability and viability of tissue constructs through a novel microgel support, optimizing for diverse tissue types and in vivo applications. | ERC Proof of... | € 150.000 | 2022 | Details |
Human based bioinks to engineer physiologically relevant tissuesHumanINK aims to validate human-based bioinks for 3D bioprinting, creating advanced cell culture environments to enhance drug development and reduce reliance on animal testing. | ERC Proof of... | € 150.000 | 2022 | Details |
Bioactive reinforcing bioink for hybrid bioprinting of implantable boneThe project aims to develop 'BioForceInk,' a bioactive bioink for hybrid 3D bioprinting of vascularized bone implants, enhancing mechanical strength and biological functionality for clinical applications. | ERC Proof of... | € 150.000 | 2024 | Details |
Jam with the flow: Microgel-based (bio)inks that assemble during printingDeveloping microgel-based materials for extrusion-based 3D printing to create stable, heterogeneous scaffolds with precise control over local properties for biomedical applications. | ERC Starting... | € 2.075.000 | 2025 | Details |
4D bioprinting shape-morphing tissues using phototunable supramolecular hydrogelsmorphoPRINT aims to develop a dynamic hydrogel platform for bioprinted tissues that enables programmable shape-morphing, facilitating the creation of functional organs through controlled volumetric growth. | ERC Starting... | € 1.499.906 | 2023 | Details |
A novel support material for 3D bioprinting and post-printing tissue growth: Print and Grow
The "Print and Grow" project aims to enhance 3D bioprinting stability and viability of tissue constructs through a novel microgel support, optimizing for diverse tissue types and in vivo applications.
Human based bioinks to engineer physiologically relevant tissues
HumanINK aims to validate human-based bioinks for 3D bioprinting, creating advanced cell culture environments to enhance drug development and reduce reliance on animal testing.
Bioactive reinforcing bioink for hybrid bioprinting of implantable bone
The project aims to develop 'BioForceInk,' a bioactive bioink for hybrid 3D bioprinting of vascularized bone implants, enhancing mechanical strength and biological functionality for clinical applications.
Jam with the flow: Microgel-based (bio)inks that assemble during printing
Developing microgel-based materials for extrusion-based 3D printing to create stable, heterogeneous scaffolds with precise control over local properties for biomedical applications.
4D bioprinting shape-morphing tissues using phototunable supramolecular hydrogels
morphoPRINT aims to develop a dynamic hydrogel platform for bioprinted tissues that enables programmable shape-morphing, facilitating the creation of functional organs through controlled volumetric growth.