SubsidieMeestersFocused Ultrasound Personalized Therapy for the Treatment of Depression (UPSIDE)
The UPSIDE project aims to develop a minimally invasive hybrid neurotechnology for targeted brain stimulation and biomarker monitoring to enhance treatment for Treatment-Resistant Depression.
Projectdetails
Introduction
Major depressive disorder (MDD) is the leading cause of disability worldwide, affecting 300 million people with a lifetime prevalence of 15%. Approximately one third of all MDD patients fail to respond to currently established treatments based on medication and psychotherapy, thus falling into the category of Treatment-Resistant Depression (TRD) patients.
Current Treatment Limitations
Electroconvulsive therapy (ECT), repetitive Transcranial Magnetic Stimulation (tRMS), Vagus nerve stimulation, deep brain stimulation (DBS), and transcranial focused ultrasound (tFUS) still show:
- Poor spatial resolution (ECT, tRMS, tFUS)
- Low network coverage (VNS, DBS)
Average remission rates in clinical trials remain lower than 30%.
Need for Biomarkers
Apart from the existing stimulation hurdles, reliable biomarkers for depression are needed as a diagnostic tool. In the case of neurotechnology (NT), these biomarkers can help determine stimulation efficacy and allow for personalized treatment.
Project Overview
The UPSIDE project proposes a minimally invasive, high spatial resolution, and multi-brain region stimulation and recording system to largely exceed the capabilities of existing NT for depression.
Objectives
Our objective is to research and validate in vivo a hybrid neurotechnology consisting of:
- An epidural focused ultrasound (eFUS) stimulator employing three-dimensional beamforming
- A high-density epidural EEG recording system
Technological Innovations
Epidural deployment of these devices will be enabled by novel methods for:
- Massive integration and miniaturization of high-performing piezoelectric ultrasound materials
- High-fidelity organic bioelectronic materials with high energy-efficient complementary metal-oxide semiconductor (CMOS) technology in a biocompatible manner
Expected Outcomes
The UPSIDE project will result in a demonstrator which will allow, for the first time, network stimulation and simultaneous biomarker readout in behavioral experiments with animal models featuring depression-like symptoms. This technological breakthrough will pave the way towards a personalized treatment for TRD.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 4.149.921 |
| Totale projectbegroting | € 4.149.921 |
Tijdlijn
| Startdatum | 1-9-2022 |
| Einddatum | 31-8-2026 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- TECHNISCHE UNIVERSITEIT DELFTpenvoerder
- UNIVERSITEIT GENT
- UNIVERSITAETSKLINIKUM FREIBURG
- NEWRONIKA SPA
- SILICONGATE LDA
- Micro Systems Technologies Management GmbH
- FOCUSED ULTRASOUND FOUNDATION
Land(en)
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Closed-loop Individualized image-guided Transcranial Ultrasonic Stimulation
The project aims to develop a neuronavigated transcranial ultrasound stimulation (TUS) system for precise, non-invasive modulation of deep brain structures to treat neurological and psychiatric disorders.
AEGEUS - A Novel EEG Ultrasound Device for Functional Brain Imaging and Neurostimulation
Develop a novel wearable device combining ultrasound imaging and EEG for enhanced diagnosis and treatment of neurological disorders, aiming for improved patient outcomes and research advancements.
MagnetoElectric and Ultrasonic Technology for Advanced BRAIN modulation
META-BRAIN aims to develop non-invasive, precise control of brain activity using magnetoelectric nanoarchitectures and ultrasonic technologies, enhancing treatment for neurological disorders.
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Project RELIEVE aims to develop a non-invasive closed-loop system using AI and wearable ultrasound for real-time monitoring and intervention in brain disorders, starting with epilepsy treatment.
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Minimally invasive and closed-loop ultrasound neuromodulation and recording for the treatment of focal epilepsyThis project aims to develop a minimally invasive, closed-loop ultrasound neuromodulation system for treating refractory epilepsy, optimizing protocols through a comprehensive computational framework. | ERC Starting... | € 1.499.575 | 2025 | Details |
Deep Brain Neuromodulation using Temporal Interference Magnetic StimulationDevelop a non-invasive tool using temporal interference magnetic stimulation for precise modulation of neural activity in the brain, aiming to improve treatment options for brain disorders. | ERC Proof of... | € 150.000 | 2022 | Details |
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Dissecting the biophysical mechanisms of deep brain stimulation using voltage fluorescence microscopyThis project aims to elucidate the cellular mechanisms of deep brain stimulation in epilepsy using a novel optical technique to improve therapeutic protocols for human patients. | ERC Starting... | € 1.498.729 | 2024 | Details |
Bidirectional Brain/Neural-Computer Interaction for Restoration of Mental Health
This project aims to develop a portable neuromodulation system using quantum sensors and magnetic stimulation to precisely target brain oscillations for treating mental health disorders.
Minimally invasive and closed-loop ultrasound neuromodulation and recording for the treatment of focal epilepsy
This project aims to develop a minimally invasive, closed-loop ultrasound neuromodulation system for treating refractory epilepsy, optimizing protocols through a comprehensive computational framework.
Deep Brain Neuromodulation using Temporal Interference Magnetic Stimulation
Develop a non-invasive tool using temporal interference magnetic stimulation for precise modulation of neural activity in the brain, aiming to improve treatment options for brain disorders.
MODular and EXpandable multi-locus Transcranial Magnetic Stimulation
Develop an affordable, automated multi-locus TMS system to enhance brain stimulation efficiency and efficacy, improving treatment outcomes for various neurological disorders.
Dissecting the biophysical mechanisms of deep brain stimulation using voltage fluorescence microscopy
This project aims to elucidate the cellular mechanisms of deep brain stimulation in epilepsy using a novel optical technique to improve therapeutic protocols for human patients.