SubsidieMeestersFocused Ultrasound Personalized Therapy for the Treatment of Depression (UPSIDE)
The UPSIDE project aims to develop a minimally invasive hybrid neurotechnology for targeted brain stimulation and biomarker monitoring to enhance treatment for Treatment-Resistant Depression.
Projectdetails
Introduction
Major depressive disorder (MDD) is the leading cause of disability worldwide, affecting 300 million people with a lifetime prevalence of 15%. Approximately one third of all MDD patients fail to respond to currently established treatments based on medication and psychotherapy, thus falling into the category of Treatment-Resistant Depression (TRD) patients.
Current Treatment Limitations
Electroconvulsive therapy (ECT), repetitive Transcranial Magnetic Stimulation (tRMS), Vagus nerve stimulation (VNS), deep brain stimulation (DBS), and transcranial focused ultrasound (tFUS) still show:
- Poor spatial resolution (ECT, tRMS, tFUS)
- Low network coverage (VNS, DBS)
With average remission rates in clinical trials still lower than 30%.
Need for Biomarkers
Apart from the existing stimulation hurdles, reliable biomarkers for depression are needed as a diagnostic tool. In the case of neurotechnology (NT), these biomarkers can help determine stimulation efficacy and allow for personalized treatment.
Project Overview
The UPSIDE project proposes a minimally invasive, high spatial resolution, and multi-brain region stimulation and recording system to largely exceed the capabilities of existing NT for depression.
Objectives
Our objective is to research and validate in vivo a hybrid neurotechnology consisting of:
- An epidural focused ultrasound (eFUS) stimulator employing three-dimensional beamforming
- A high-density epidural EEG recording system
Technological Innovations
Epidural deployment of these devices will be enabled by novel methods for:
- Massive integration and miniaturization of high-performing piezoelectric ultrasound materials
- High-fidelity organic bioelectronic materials
- High energy-efficient complementary metal-oxide semiconductor (CMOS) technology in a biocompatible manner
Expected Outcomes
The UPSIDE project will result in a demonstrator which will allow, for the first time, network stimulation and simultaneous biomarker readout in behavioral experiments with animal models featuring depression-like symptoms.
This technological breakthrough will pave the way towards a personalized treatment for TRD.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 4.149.921 |
| Totale projectbegroting | € 4.149.921 |
Tijdlijn
| Startdatum | 1-9-2022 |
| Einddatum | 31-8-2026 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- TECHNISCHE UNIVERSITEIT DELFTpenvoerder
- UNIVERSITEIT GENT
- UNIVERSITAETSKLINIKUM FREIBURG
- NEWRONIKA SPA
- SILICONGATE LDA
- Micro Systems Technologies Management GmbH
- FOCUSED ULTRASOUND FOUNDATION
Land(en)
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