Nanotechnology-enabled deep profiling of the blood and brain proteome at the intersection of neurodegeneration and neurooncology
NanoNeuroOmics aims to discover early blood biomarkers for Alzheimer's and Glioblastoma using nanotechnology and proteomics to bridge the gap between brain and blood molecular changes.
Projectdetails
Introduction
NanoNeuroOmics ambition is to bring together nanotechnology, proteomics and blood biomarker discovery at the emerging intersection of neurodegeneration and neurooncology.
Proposed Solution
NanoNeuroOmics proposes a nanotechnology-based innovative solution for the integrative profiling of the blood and brain tissue proteomes to address two interconnected challenges:
- The unmet clinical need for early diagnostic and disease-monitoring blood biomarkers for two of the most challenging Central Nervous System disorders, namely Alzheimer’s disease (AD) and Glioblastoma (GBM).
- The AD-GBM ‘inverse comorbidity’ knowledge gap and intriguing molecular interrelation.
Novel Approach
NanoNeuroOmics presents a novel approach, in which nanoparticles are employed as scavenging agents to uncover brain disease-specific protein markers in blood, otherwise buried under the overwhelming signal of highly abundant molecules.
Technological Challenge
NanoNeuroOmics aims to tackle the technological challenge of discovering highly specific blood biomarkers by longitudinally tracking blood and brain proteomic signals at different stages of disease progression.
Research Programme
To leverage its full potential, the proposed research programme combines longitudinal preclinical studies with human patient clinical validation studies.
Expected Outcomes
Such multi-dimensional proteomic approaches are expected to pioneer new blood biomarker discoveries and to provide mechanistic insight into the comorbidity of neurological diseases.
Goals
NanoNeuroOmics attempts to discover a distinct set of dysregulated proteins for each of AD and GBM independently and to unveil overlapping molecular pathways to explain the AD-GBM inverse comorbidity.
Broader Context
In a broader context, NanoNeuroOmics aspires to bridge the gap between brain pathophysiology and molecular alterations in the blood, across the biological continuum of disease progression.
Multidisciplinary Approach
The project takes on a multidisciplinary approach and builds on breakthroughs in nanotechnology and omics sciences, to advance early detection and stratified medicine.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 1.494.954 |
Totale projectbegroting | € 1.494.954 |
Tijdlijn
Startdatum | 1-1-2025 |
Einddatum | 31-12-2029 |
Subsidiejaar | 2025 |
Partners & Locaties
Projectpartners
- THE UNIVERSITY OF MANCHESTERpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
Project | Regeling | Bedrag | Jaar | Actie |
---|---|---|---|---|
MANUNKIND: Determinants and Dynamics of Collaborative ExploitationThis project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery. | ERC STG | € 1.497.749 | 2022 | Details |
Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressureThe UnderPressure project aims to investigate how mechanical constraints from 3D crowding affect cell proliferation and signaling in various organisms, with potential applications in reducing cancer chemoresistance. | ERC STG | € 1.498.280 | 2022 | Details |
Uncovering the mechanisms of action of an antiviral bacteriumThis project aims to uncover the mechanisms behind Wolbachia's antiviral protection in insects and develop tools for studying symbiont gene function. | ERC STG | € 1.500.000 | 2023 | Details |
The Ethics of Loneliness and SociabilityThis project aims to develop a normative theory of loneliness by analyzing ethical responsibilities of individuals and societies to prevent and alleviate loneliness, establishing a new philosophical sub-field. | ERC STG | € 1.025.860 | 2023 | Details |
MANUNKIND: Determinants and Dynamics of Collaborative Exploitation
This project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery.
Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressure
The UnderPressure project aims to investigate how mechanical constraints from 3D crowding affect cell proliferation and signaling in various organisms, with potential applications in reducing cancer chemoresistance.
Uncovering the mechanisms of action of an antiviral bacterium
This project aims to uncover the mechanisms behind Wolbachia's antiviral protection in insects and develop tools for studying symbiont gene function.
The Ethics of Loneliness and Sociability
This project aims to develop a normative theory of loneliness by analyzing ethical responsibilities of individuals and societies to prevent and alleviate loneliness, establishing a new philosophical sub-field.
Vergelijkbare projecten uit andere regelingen
Project | Regeling | Bedrag | Jaar | Actie |
---|---|---|---|---|
Fluid Biomarkers for Neurodegenerative DementiasThe project aims to develop high-throughput biomarker tools for Alzheimer's and neurodegenerative diseases, enabling comprehensive analysis for diagnostics, drug discovery, and personalized medicine. | ERC ADG | € 2.422.973 | 2022 | Details |
4D Brain-Targeting Nanomedicines for Treating NeurodegenerationThis project aims to develop advanced 4D-brain-targeting nanoparticles using nanotechnology to effectively deliver treatments for neurodegenerative diseases across the blood-brain barrier. | ERC COG | € 2.000.000 | 2023 | Details |
Novel biomarkers for improving diagnostics, prognostics, and treatments of Alzheimer’s diseaseADVANCE-AD aims to enhance Alzheimer's diagnostics and treatment by developing cost-effective blood-based biomarkers and algorithms for early detection and intervention in pre-symptomatic patients. | ERC ADG | € 2.500.000 | 2024 | Details |
integrated nano-photonic OMICs bio-SENSor for lung cancerOMICSENS aims to develop a novel nano-photonic omics bio-sensor for real-time detection of TKI resistance in NSCLC, enhancing prognosis and paving the way for personalized cancer treatment. | EIC Pathfinder | € 2.372.318 | 2024 | Details |
Fluid Biomarkers for Neurodegenerative Dementias
The project aims to develop high-throughput biomarker tools for Alzheimer's and neurodegenerative diseases, enabling comprehensive analysis for diagnostics, drug discovery, and personalized medicine.
4D Brain-Targeting Nanomedicines for Treating Neurodegeneration
This project aims to develop advanced 4D-brain-targeting nanoparticles using nanotechnology to effectively deliver treatments for neurodegenerative diseases across the blood-brain barrier.
Novel biomarkers for improving diagnostics, prognostics, and treatments of Alzheimer’s disease
ADVANCE-AD aims to enhance Alzheimer's diagnostics and treatment by developing cost-effective blood-based biomarkers and algorithms for early detection and intervention in pre-symptomatic patients.
integrated nano-photonic OMICs bio-SENSor for lung cancer
OMICSENS aims to develop a novel nano-photonic omics bio-sensor for real-time detection of TKI resistance in NSCLC, enhancing prognosis and paving the way for personalized cancer treatment.