Nanotechnology-enabled deep profiling of the blood and brain proteome at the intersection of neurodegeneration and neurooncology

NanoNeuroOmics aims to discover early blood biomarkers for Alzheimer's and Glioblastoma using nanotechnology and proteomics to bridge the gap between brain and blood molecular changes.

Subsidie
€ 1.494.954
2025

Projectdetails

Introduction

NanoNeuroOmics ambition is to bring together nanotechnology, proteomics and blood biomarker discovery at the emerging intersection of neurodegeneration and neurooncology.

Proposed Solution

NanoNeuroOmics proposes a nanotechnology-based innovative solution for the integrative profiling of the blood and brain tissue proteomes to address two interconnected challenges:

  1. The unmet clinical need for early diagnostic and disease-monitoring blood biomarkers for two of the most challenging Central Nervous System disorders, namely Alzheimer’s disease (AD) and Glioblastoma (GBM).
  2. The AD-GBM ‘inverse comorbidity’ knowledge gap and intriguing molecular interrelation.

Novel Approach

NanoNeuroOmics presents a novel approach, in which nanoparticles are employed as scavenging agents to uncover brain disease-specific protein markers in blood, otherwise buried under the overwhelming signal of highly abundant molecules.

Technological Challenge

NanoNeuroOmics aims to tackle the technological challenge of discovering highly specific blood biomarkers by longitudinally tracking blood and brain proteomic signals at different stages of disease progression.

Research Programme

To leverage its full potential, the proposed research programme combines longitudinal preclinical studies with human patient clinical validation studies.

Expected Outcomes

Such multi-dimensional proteomic approaches are expected to pioneer new blood biomarker discoveries and to provide mechanistic insight into the comorbidity of neurological diseases.

Goals

NanoNeuroOmics attempts to discover a distinct set of dysregulated proteins for each of AD and GBM independently and to unveil overlapping molecular pathways to explain the AD-GBM inverse comorbidity.

Broader Context

In a broader context, NanoNeuroOmics aspires to bridge the gap between brain pathophysiology and molecular alterations in the blood, across the biological continuum of disease progression.

Multidisciplinary Approach

The project takes on a multidisciplinary approach and builds on breakthroughs in nanotechnology and omics sciences, to advance early detection and stratified medicine.

Financiële details & Tijdlijn

Financiële details

Subsidiebedrag€ 1.494.954
Totale projectbegroting€ 1.494.954

Tijdlijn

Startdatum1-1-2025
Einddatum31-12-2029
Subsidiejaar2025

Partners & Locaties

Projectpartners

  • THE UNIVERSITY OF MANCHESTERpenvoerder

Land(en)

United Kingdom

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