SubsidieMeestersExercised breastmilk: a kick-start for childhood obesity prevention
This project aims to investigate how maternal exercise during lactation alters breastmilk composition and its potential impact on reducing infant obesity risk through randomized trials and multi-omics analysis.
Projectdetails
Introduction
Innovative preventive strategies are urgently required to halt the rising prevalence of childhood obesity given the inefficacy of current interventions. Mother-to-child transmission of obesity accounts for a large proportion of childhood obesity, more than what can be explained by genes.
Importance of Early Nutrition
Nutrition during the first 3 months of life is crucial, with rapid weight gain in this period associated with subsequent obesity. Breastmilk is considered optimal for infant nutrition, but its composition depends on the mother's metabolic health. The concentrations of some breastmilk compounds linked to infant obesity are associated with maternal body mass index.
Maternal Lifestyle Factors
Maternal lifestyle factors, such as diet, can alter breastmilk composition. Little is, however, known about the effect of exercise during lactation. Exercise is a major regulator of systemic metabolism affecting multiple tissues and organs.
Project Overview
In this ambitious, inter-disciplinary project, I will determine how exercise during lactation influences breastmilk composition in women with overweight/obesity and whether exercise-induced changes in breastmilk will influence infant obesity risk.
Preliminary Data
My preliminary data show acute effects of exercise on breastmilk concentrations of adiponectin and lipid metabolites relevant for energy metabolism.
Research Goals
In ExMilk, I will determine both acute effects and adaptations after regular exercise on a complex matrix of breastmilk compounds. By linking breastmilk data to comprehensive data for the infants, I will investigate the potential mechanisms underlying the effects of maternal exercise on infant obesity risk, mediated by changes in breastmilk composition.
Methodology
To reach my goals, I will perform gold-standard randomized trials and analyze biological samples from mothers and infants on multi-omics platforms. My experience in metabolomics and exercise intervention trials in reproductive-aged women will enable me to break new ground in understanding how exercise during lactation modifies infant obesity risk.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.891.529 |
| Totale projectbegroting | € 1.891.529 |
Tijdlijn
| Startdatum | 1-3-2023 |
| Einddatum | 29-2-2028 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNUpenvoerder
Land(en)
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This project aims to develop non-invasive optical tools to quantify milk transfer and investigate mammary physiology, enhancing breastfeeding support and addressing lactation insufficiency.
MOdelling THe Evolution of the mother-infant RelationshipS
MOTHERS aims to analyze dental enamel to reconstruct ancient human diets and maternal health, enhancing understanding of mother-infant relationships and informing modern public health policies.
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