Precision Nutrition to optimize immune response for metabolic health

Introduction

NUTRIMMUNE examines how dietary factors affect immune responses across varying degrees of obesity-related Noncommunicable Disease (NCD) severity. This focus is crucial given obesity’s link to NCDs and infection risks. The project gathers 6 academic groups and 1 SME across 4 European countries over 4 years and a €4.3M grant to evaluate the interplay between nutrition, glycome, microbiome, and immune health in obesity and immune impairment.

Project Partners

NUTRIMMUNE leverages partners:

1. Access to European databases and biobanks, enabling in-depth analysis at cellular and molecular levels.
2. Proficiency in conducting dietary intervention studies in human subjects.
3. Experience in mechanistic and functional diet-glycome-microbiome interactions.

Work Packages

WP1: Phenotypic and Multi-Omics Analysis

In WP1, the project deciphers phenotypic, multi-omics, and dietary factors responsible for variability in Immune Checkpoint (ICP) expression and immune impairment in existing cohorts.

WP2: Nutritional Intervention

WP2 focuses on a 24-week precision nutritional intervention to assess the potential of a pro-immune diet to restore T cell fitness in obese subjects.

WP3: Comprehensive Profiling

WP3 conducts comprehensive profiling before and after the dietary intervention, examining innate and adaptive responses, cytokine patterns, alongside ICP labeling.

WP4: Mechanistic Insights

WP4 provides mechanistic aspects on how the diet, glycome, and microbiome influence immune health.

WP5: Machine Learning Models

WP5 employs machine learning models to identify predictive markers and signatures for ICP expression and altered immunity, to identify dietary patterns and food affecting immune function.

WP6: Project Management

WP6 ensures efficient project management and effective coordination, ethics compliance, dissemination, and exploitation.

WP7: Synergies Exploration

WP7 explores synergies with portfolio projects for challenge goals.

Project Goal

The project’s goal is to move from our novel idea that precision nutrition influences immunity via microbiome and glycome, and present validated proof-of-concept evidence for nutritional recommendations and future food development.