SubsidieMeestersPreterm Brain-Oxygenation and Metabolic EU-Sensing: Feed the Brain
Prometeus aims to personalize nutrition for premature neonates in NICUs through real-time adjustments of glucose and nutrients based on brain needs, reducing the risk of neurodevelopmental disabilities.
Projectdetails
Introduction
Prometeus introduces a new paradigm for personalized nutrition of prematurely born neonates in neonatal intensive care units (NICU) by developing a groundbreaking technology for real-time adjustment of glucose and nutrient intakes to target neonatal brain needs.
Importance of Nutrition
The brain of a baby born prematurely is highly susceptible to early neonatal injuries that, in turn, increase the risk for neurodevelopmental disability. Provision of adequate nutrients and oxygen is essential for proper brain development and growth.
Current Challenges
However, current nutritional strategies are unfit to target real-time brain necessities and are driven by pre-specified (non-personalized) nutritional charts, in the absence of contemporary cot-side monitoring of both brain “health” and metabolic supplies.
As a consequence, sudden changes in brain fuel requirements cannot be promptly addressed by real-time adjustment of glucose and nutrient provision.
Development of a Metabolic Model
Prometeus will develop a metabolic model of the interaction between the three key brain fuels:
- Glucose
- Lactate
- Beta-hydroxybutyrate (BHB)
This model will assess their effect on regional cerebral blood flow (CBF), oxygen saturation (StO2), and metabolism (CMRO2). The model will serve to individualize brain nutrition targeting “brain health” according to the inputs derived from two novel minimally invasive metabolic sensing systems:
- A wearable cap measuring regional CBF, StO2, and CMRO2
- A subcutaneous miniaturized metabolic sensor for glucose, lactate, and BHB
Creating a Metabolic "Womb"
The system will create a metabolic “womb” to feed the brain of preterm neonates.
Parent-Dedicated Interface
Prometeus will be paralleled by a parent-dedicated interface, exploiting a purposely developed family-adjusted visual language, that will inform parents of preterm babies during their NICU admission and stay.
Expected Impact
Prometeus will dramatically reduce the risk for prematurity-associated disability in Europe and worldwide, with a consequent incalculable ethical, social, and economic impact.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 3.554.156 |
| Totale projectbegroting | € 3.554.156 |
Tijdlijn
| Startdatum | 1-2-2023 |
| Einddatum | 31-1-2027 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- UNIVERSITA DEGLI STUDI DI PADOVApenvoerder
- QULAB MEDICAL LTD.
- UNIVERSITAT DE GIRONA
- POLITECNICO DI MILANO
- PIONIRS SRL
- FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
- DAVE SRL
- UNIVERSITE GRENOBLE ALPES
- UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
- INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
- UNIVERSITY COLLEGE LONDON
Land(en)
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Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
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A tool to detect cognitive abnormalities in the first year of life based on electroencephalography (EEG)The babylearn project aims to develop an EEG-based tool for early assessment of cognitive functions in infants, enhancing diagnosis and support for at-risk populations like premature babies. | ERC Proof of... | € 150.000 | 2023 | Details |
A first-in-class therapy for intestinal malabsorption in premature newbornsELGN-GI is a pioneering drug aimed at accelerating gut maturation in preterm infants, reducing reliance on parenteral nutrition and lowering risks of infections and complications. | EIC Accelerator | € 2.359.000 | 2022 | Details |
WEE-DetectWEE-Detect onderzoekt het verbeteren van een slim luierplatform voor continue urine-monitoring van neonaten om overlevingskansen te vergroten. | Mkb-innovati... | € 20.000 | 2021 | Details |
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Premature baby's draadloos monitoren met de Bambi Belt
Het project ontwikkelt de Bambi Belt, een draadloos en huidvriendelijk monitoringsysteem voor premature baby’s, om stress en pijn te verminderen en de kwaliteit van zorg te verbeteren, wat ziekenhuisverblijven verkort en kosten verlaagt.
A tool to detect cognitive abnormalities in the first year of life based on electroencephalography (EEG)
The babylearn project aims to develop an EEG-based tool for early assessment of cognitive functions in infants, enhancing diagnosis and support for at-risk populations like premature babies.
A first-in-class therapy for intestinal malabsorption in premature newborns
ELGN-GI is a pioneering drug aimed at accelerating gut maturation in preterm infants, reducing reliance on parenteral nutrition and lowering risks of infections and complications.
WEE-Detect
WEE-Detect onderzoekt het verbeteren van een slim luierplatform voor continue urine-monitoring van neonaten om overlevingskansen te vergroten.
Slimme luier voor vroeg geboren neonaten
Het project ontwikkelt een slimme, wegwerpbare luier met sensoren voor continue, draadloze monitoring van urinelozing bij vroeggeboren kinderen, ter verbetering van zorg en efficiëntie voor zorgprofessionals.