SubsidieMeestersCHerenkov Light mOdulE for time-of-flight Positron Emission Tomography
The CHLOE-PET project aims to develop an advanced gamma detector for TOF-PET that enhances time and spatial resolution by up to 7 and 10 times, improving cancer diagnostics without extra costs.
Projectdetails
Introduction
Time-of-flight positron emission tomography (TOF-PET) is the standard-of-care in cancer detection. TOF-PET scanners’ performance is dependent on the radiation detectors they use. Improving time and spatial detection features in such detectors will dramatically impact the diagnostic capacity of TOF-PET systems.
Project Goal
The goal of this project is to build a gamma detector concept for TOF-PET able to improve the time resolution and spatial segmentation of state-of-the-art detectors by a factor of up to 7 and 10, respectively, without additional production costs.
CHLOE-PET Design
CHLOE-PET is a forward-looking gamma detector design for TOF-PET able to exploit the new photodetector technologies that are currently under development and will become available within the next 5-to-10 years.
Novelty of the Design
The novelty of the proposed design lies in the following aspects:
- Using Cherenkov light as a prompt time source.
- Utilizing an innovative geometry optimized to maximize light collection.
- Employing photodetectors with small pixel pitch.
This project is the first attempt to build a detector module scalable to a full-size system that can be used in a hospital setting.
Detector Specifications
The CHLOE-PET detector will consist of bismuth germanate (BGO) crystals with 12 mm thickness and will combine the readout of scintillation and Cherenkov light.
Performance Metrics
CHLOE-PET will provide:
- An effective 3D segmentation of 2x2x2 mm³.
- An intrinsic photon time spread of 20 ps.
- No intrinsic radiation background (unlike state-of-the-art TOF-PET detectors).
Expected Improvements
Such improvements will allow for:
- Increasing the signal-to-noise ratio of images by >2-fold.
- Detecting lesions of 2 mm size (>3 times the current performance).
- Building portable high-performance organ-dedicated TOF-PET systems.
- Universalizing the use of dynamic TOF-PET studies.
Impact
The combination of these outcomes will provide significantly better diagnostic capabilities in a range of fields such as oncology, neurology, or cardiology, among others, and ultimately boost treatment efficacy and patient comfort.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.384.755 |
| Totale projectbegroting | € 1.384.755 |
Tijdlijn
| Startdatum | 1-9-2023 |
| Einddatum | 31-8-2027 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- INSTITUTO DE FISICA DE ALTAS ENERGIASpenvoerder
Land(en)
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