SubsidieMeestersReprogramming of Tumor Stroma to Enhance Cancer Immunotherapy
This project aims to enhance cancer immunotherapy effectiveness in solid tumors by targeting tumor-activated mesenchymal stromal cells within the immunosuppressive tumor microenvironment.
Projectdetails
Introduction
Cancer immunotherapies have shown impressive success in cancer treatment. However, these therapies are limited to certain types of cancers, and the success rate is still low.
Challenges in Solid Tumors
In particular, certain types of solid tumors containing an abundant stroma, which represent a majority of epithelial-derived cancers, respond very poorly to immunotherapies.
Tumor Microenvironment
In these tumors, a major challenge for the development of novel cancer immunotherapies is represented by the tumor microenvironment (TME). The TME is a highly hypoxic and immunosuppressive environment that prevents proper tumor infiltration and functioning of effector immune cells.
Recent Discoveries
Recent discoveries have identified tumor-activated mesenchymal stromal cells (MSCs) developing within the TME. These MSCs have been shown to represent a major brake for efficient antitumor immunity in solid tumors.
Project Goals
In this project, we will investigate the potential of a novel approach and therapeutic avenue to:
- Target specific populations of MSCs within the TME.
- Determine the synergistic effect with immunotherapies to improve treatment efficacy in solid tumors.
Long-term Vision
In the long term, this project aims at overcoming a major barrier in utilizing cancer immunotherapies in solid tumors.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-6-2024 |
| Einddatum | 30-11-2025 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- INSTITUT PASTEURpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
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This project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery.
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|---|---|---|---|---|
Developing novel single-cell technologies to model and perturb intra-tumor interactions and signaling – an innovation program for the next generation of immunotherapiesThe TROJAN-Cell project aims to engineer immune responses against tumors by understanding immune-suppressive mechanisms in the tumor microenvironment using advanced single-cell technologies. | ERC ADG | € 2.500.000 | 2022 | Details |
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This project aims to map immune and stromal cell interactions in the tumor microenvironment to develop targeted therapies that enhance immunotherapy efficacy against cancer.
Novel peptide-based therapeutics for reprogramming the tumour stroma extracellular matrix using molecular modelling and computational engineering
The project aims to develop TAX2, a novel peptide therapy targeting the tumor microenvironment to inhibit solid tumor progression and enhance immunotherapy efficacy, with a focus on ovarian cancer.