Personalised Bioelectronics for Epithelial Repair
ProBER aims to develop personalized bioelectronic wound dressings using conformal DC electrodes to enhance healing speed and efficiency in chronic wounds, preparing for clinical studies.
Projectdetails
Introduction
Care of chronic wounds constitutes an enormous socioeconomic burden to the European Healthcare system, calling for new strategies to support healing for wounds at risk. As a restored epithelium will outperform any artificial scaffold in protecting the underlying tissue, fast re-epithelialization is the primary goal.
Current Findings
In culture models of wound healing, we have shown that direct current stimulation (DCs) makes epithelial ruptures close up to three times faster, and that the key to success is dosage. This aspect is overlooked in previous clinical studies. Typically, DCs thresholds established in cultures are lost in translation due to the lack of technologies able to support DCs on the skin.
Project Overview
In ProBER, we will change this. We will exploit technologies for making conformal, metal-free, biocompatible DCs electrodes for skin developed in the ERC StG SPEEDER. By focusing on personalization of the bioelectronic wound dressing, we will ensure that the same efficient parameter space established in culture models can be precisely replicated on actual wounds.
Goals and Methodology
Our goal is a fabrication pipeline with wound dressings tailored to the wound. We will:
- Collect information on wound size and shape using LIDAR 3D scanning.
- Feed this information, as well as impedance measurements, to an automated personalization algorithm.
Personalization extends beyond fabrication, as the ProBER wound dressing will include integrated impedance sensors to ensure that DCs is adapted to the healing progress.
Future Directions
In ProBER, we will prepare our promising concept for subsequent clinical studies, which requires a functional concept for fabrication and proof-of-concept demonstration. We will co-develop our wound dressing together with stakeholders in healthcare, and work to:
- Protect intellectual property (IP)
- Recruit strategic partners
- Form alliances for clinical translation
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 150.000 |
Totale projectbegroting | € 150.000 |
Tijdlijn
Startdatum | 1-6-2023 |
Einddatum | 30-11-2024 |
Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- CHALMERS TEKNISKA HOGSKOLA ABpenvoerder
Land(en)
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