SubsidieMeestersMultianalyte Continuum Nanopores Sensing
MC-Nano aims to develop a real-time nanopore sensing tool for continuous monitoring of heart failure biomarkers in urine, enhancing diagnostic accuracy and personalizing patient treatment.
Projectdetails
Introduction
Diagnostic limitations in healthcare form a major societal challenge, especially in the case of heart failure. More than 15 million Europeans suffer from heart failure, with a projected increase of up to 33% in heart failure patients globally by 2060.
Importance of Natriuresis-Guided Therapy
An important instrument for better diagnoses of heart failure comes from natriuresis-guided therapy, offering potential for personalized treatment. Monitoring natriuresis through urinalysis via Point of Care Testing (POCT) helps manage severe heart failure.
Challenges of POCT
However, POCT presents several complications:
- It can only be performed by healthcare professionals.
- Long-term costs are high.
Project Overview
Responding to these challenges, this ERC Proof of Concept (PoC) proposal introduces "Multianalyte Continuum Nanopores Sensing" (MC-Nano), led by Prof. Giovanni Maglia.
Objectives of MC-Nano
MC-Nano aims to develop a biological nanopore tool for real-time continuous patient health monitoring to improve possibilities of POCT. The project will develop a nanopore system to detect:
- Sodium ions
- Electrolytes
- Proteins
- Heart failure biomarkers in liquid samples like urine
Advantages of the Nanopore System
By utilizing multiple nanopores, the system improves accuracy and reliability in identifying pathologies related to heart failure, including kidney failure. The project's advantages include:
- Potential for miniaturization
- Minimal need for specialized solutions
- Compatibility with low-powered electronic devices
Foundation of the Project
Built upon the foundations of a previous project, ERC CoG De-Nano, which successfully developed biological nanopores for peptide and protein sequencing, this proposal aspires to take the first steps toward the design of an innovative diagnostic device tailored for continuous monitoring of heart failure patients, tracing natriuretic activity in real-time.
Future Implications
The resulting technology aims to substantially reduce the limitations of current diagnostic methods for heart failure patients globally and paves the way for precise and efficient medical interventions in the future.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-4-2024 |
| Einddatum | 30-9-2025 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- RIJKSUNIVERSITEIT GRONINGENpenvoerder
Land(en)
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Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
The first heart failure therapy management point-of-care device with multiplex and multimodal sensorCardioCap is a handheld POC device that uses a finger-prick blood sample to simultaneously assess heart failure severity through four biomarkers, aiming to reduce re-hospitalization and mortality rates by 30%. | EIC Accelerator | € 2.499.999 | 2025 | Details |
New Generation HealthcareToxgensolutions onderzoekt de toepassing van miR-technologie voor vroege diagnose van ziekten met een nanotechnologie microsensor. | Mkb-innovati... | € 20.000 | 2022 | Details |
Acute Heart FailureHet project richt zich op het ontwikkelen van een platform voor real-time meting van urine-biomarkers bij acuut hartfalen. | 1.1 - Onderz... | € 598.145 | 2023 | Details |
Haalbaarheidsonderzoek: portable nanopore device voor de identificatie van eiwitten en biomarkers.Portal Biotech ontwikkelt een draagbaar analysetoestel op basis van nanopore technologie om real-time eiwitmetingen mogelijk te maken, wat de diagnostiek revolutionair verandert. | Mkb-innovati... | € 20.000 | 2022 | Details |
Boost of DiureticsHet project ontwikkelt een goedkope en effectieve methode voor thuismonitoring van hart- en longfalen, gericht op het tijdig signaleren van verslechtering om zorglasten te verlichten. | Mkb-innovati... | € 20.000 | 2020 | Details |
The first heart failure therapy management point-of-care device with multiplex and multimodal sensor
CardioCap is a handheld POC device that uses a finger-prick blood sample to simultaneously assess heart failure severity through four biomarkers, aiming to reduce re-hospitalization and mortality rates by 30%.
New Generation Healthcare
Toxgensolutions onderzoekt de toepassing van miR-technologie voor vroege diagnose van ziekten met een nanotechnologie microsensor.
Acute Heart Failure
Het project richt zich op het ontwikkelen van een platform voor real-time meting van urine-biomarkers bij acuut hartfalen.
Haalbaarheidsonderzoek: portable nanopore device voor de identificatie van eiwitten en biomarkers.
Portal Biotech ontwikkelt een draagbaar analysetoestel op basis van nanopore technologie om real-time eiwitmetingen mogelijk te maken, wat de diagnostiek revolutionair verandert.
Boost of Diuretics
Het project ontwikkelt een goedkope en effectieve methode voor thuismonitoring van hart- en longfalen, gericht op het tijdig signaleren van verslechtering om zorglasten te verlichten.