A new device to analyse the regional variations of mechanical properties in cells and tissues: prototyping and assessment of commercial potential for drug discovery applications
The MECHANOMICS-POC project aims to develop and commercialize a novel multimodal technology for measuring mechanical properties in biological tissues, enhancing drug discovery and diagnostics.
Projectdetails
Introduction
Mechanomics refers to the measurement of mechanical properties at the microscopic scale in biological tissues. Strong hopes are currently placed on mechanomics to evaluate quantitatively how a treatment or a gene expression affects the stiffness or strength of a tissue, with major impacts expected in drug discovery, diagnostics, and genomics screening. However, there is a pressing need for new instrumentation technologies in mechanomics.
Technology Development
In the BIOLOCHANICS ERC CoG project, we developed and validated a novel multimodal technology addressing these challenges. Our technology can perform the following actions:
- Apply controlled loads on tissue samples.
- Measure the induced bulk deformations at the micron level.
- Map the distribution of local stiffness of these tissues.
Current Status
Our technology shows very competitive potential for mechanomics in general. However, as an innovative technology, it remains at the stage of a technological concept with a first laboratory application (TRL 2-3) achieved within the ERC CoG BIOLOCHANICS project.
Objectives
Our global objective in MECHANOMICS-POC is to reach TRL 6 in order to take it further towards a commercial innovation. This includes:
- Making a first integrated prototype.
- Testing it in an intended environment.
- Refining the comparison with existing technologies.
Our specific objectives are:
- (O1) To build an integrated user-friendly prototype.
- (O2) To determine further IPR strategy.
- (O3) To establish the commercialization strategy including market research, industrial partnerships, and lead management.
- (O4) To validate the prototype in real-world conditions and present it to industrial stakeholders in the identified sectors.
Future Exploitation
Besides the development and assessment of the prototype demonstrator, we will focus on the future exploitation and commercialization roadmap of this technology, which is aimed at becoming standard laboratory equipment or service for fundamental research in life sciences and for drug discovery applications.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 150.000 |
Totale projectbegroting | € 150.000 |
Tijdlijn
Startdatum | 1-5-2022 |
Einddatum | 31-10-2023 |
Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- INSTITUT MINES-TELECOMpenvoerder
Land(en)
Geen landeninformatie beschikbaar
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Engineering soft microdevices for the mechanical characterization and stimulation of microtissues
This project aims to advance mechanobiology by developing soft robotic micro-devices to study and manipulate 3D tissue responses, enhancing understanding of cell behavior and potential cancer treatments.
MagMech: Precision magnetic tweezers for the mechanobiology of cells and tissues.
The MagMech PoC project aims to enhance a novel magnetic tweezer system for applying and measuring forces in cells and tissues, facilitating advancements in mechanobiology and commercialization.
Intelligent Device and Computational Software to Control Mechanical Stress and Deformation for Biological Testing
ISBIOMECH aims to develop a novel intelligent system for controlling mechanical environments in biological testing, enhancing in-vitro therapies and drug discovery for various pathologies.
3D screening system to cultivate tissue and automatically stimulate and quantify its mechanical properties
The project aims to develop the TissMec system for automated 3D human tissue creation and screening to expedite drug candidate evaluation and improve the drug development process.
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This project aims to enhance Brillouin Microscopy for real-time, non-destructive assessment of viscoelastic properties in living cells, addressing key biomedical challenges.
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