SubsidieMeestersPiezoceutical biomaterial scaffolds for immunomodulatory-based myocardial repair
The PiezoMac patch aims to regenerate cardiac muscle post-myocardial infarction using optimized piezoelectric stimulation and 3D-printed designs tailored to patient-specific heart anatomy.
Projectdetails
Introduction
Cardiac injury in the form of a myocardial infarction leads to cardiac muscle death and replacement scar tissue that cannot compensate for lost heart tissue. This disease does not improve with traditional drugs and places a significant burden on healthcare budgets worldwide, resulting in a reduced quality of life for patients, often leading to heart failure.
Current Limitations
Current engineered cardiac patches do not reduce inflammation and do not integrate in a sufficient manner to compensate for the pumping power lost with the heart tissue.
The PiezoMac Patch
The PiezoMac patch differs fundamentally from patches reported up to now. It will contain an optimised piezoelectric capability that will yield electric fields generated by the stretching of the heart.
Electric Field Stimulation
This electric field stimulation will be optimised to drive immunomodulation and regeneration of the cardiac muscle.
Design and Manufacturing
The shape of the patch is pre-designed using finite element modelling to conform to the directional dependent stretching of the heart wall. Information about patient anatomy and the extent of heart attack damage will be derived from X-ray CT and MRI scans.
3D Printing Process
These smart patches will be 3D printed (using melt electrowriting) into accurate microfibrous ordered patches. The characteristics of these patches will include:
- Density
- Micro-orientation
- Fibre laydown
These factors will be informed using in silico modelling of piezoelectric generation and mechanical anisotropy.
Design Optimization
We will shortlist candidate mesh designs to match the anisotropy of the heart using finite element analysis. The design process will be refined using a Bayesian Optimisation approach to strike a balance between mechanical anisotropy and piezoelectric output, ultimately aiming to halt cardiac deterioration.
Conclusion
This pragmatic and rational approach gathers and advances cutting-edge technologies in this interdisciplinary project to address a significant unmet need in healthcare today.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.579.608 |
| Totale projectbegroting | € 2.579.608 |
Tijdlijn
| Startdatum | 1-6-2024 |
| Einddatum | 31-5-2029 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLINpenvoerder
Land(en)
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|---|---|---|---|---|
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This project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery.
Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressure
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This project aims to uncover the mechanisms behind Wolbachia's antiviral protection in insects and develop tools for studying symbiont gene function.
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Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Restoring anisotropy in living tissues 'in situ'This project aims to enhance cardiac tissue regeneration by restoring structural anisotropy using ultrasound, improving therapy outcomes through a multidisciplinary and technology-driven approach. | ERC ADG | € 3.056.887 | 2022 | Details |
Surgical optogenetic bioprinting of engineered cardiac muscleLIGHTHEART aims to revolutionize heart failure treatment by developing a surgical bioprinting tool that uses optogenetics to create engineered cardiac muscle directly at the patient's heart. | ERC STG | € 1.499.705 | 2023 | Details |
Piezo-driven theramesh: A revolutionary multifaceted actuator to repair the injured spinal cordPiezo4Spine aims to create a groundbreaking 3D bioprinted mesh therapy for spinal cord injury that enhances neural repair through targeted mechanotransduction and gene therapy. | EIC Pathfinder | € 3.537.120 | 2023 | Details |
Novel bio-inspired energy harvesting and storage all-in-one platform for implantable devices based on peptide nanotechnologyDeveloping PepZoPower, a biocompatible energy harvesting and storage device using piezoelectric peptides, to create autonomous, miniaturized power sources for implantable biomedical systems. | ERC POC | € 150.000 | 2022 | Details |
Restoring anisotropy in living tissues 'in situ'
This project aims to enhance cardiac tissue regeneration by restoring structural anisotropy using ultrasound, improving therapy outcomes through a multidisciplinary and technology-driven approach.
Surgical optogenetic bioprinting of engineered cardiac muscle
LIGHTHEART aims to revolutionize heart failure treatment by developing a surgical bioprinting tool that uses optogenetics to create engineered cardiac muscle directly at the patient's heart.
Piezo-driven theramesh: A revolutionary multifaceted actuator to repair the injured spinal cord
Piezo4Spine aims to create a groundbreaking 3D bioprinted mesh therapy for spinal cord injury that enhances neural repair through targeted mechanotransduction and gene therapy.
Novel bio-inspired energy harvesting and storage all-in-one platform for implantable devices based on peptide nanotechnology
Developing PepZoPower, a biocompatible energy harvesting and storage device using piezoelectric peptides, to create autonomous, miniaturized power sources for implantable biomedical systems.