SubsidieMeestersPiezo-driven theramesh: A revolutionary multifaceted actuator to repair the injured spinal cord
Piezo4Spine aims to create a groundbreaking 3D bioprinted mesh therapy for spinal cord injury that enhances neural repair through targeted mechanotransduction and gene therapy.
Projectdetails
Introduction
Piezo4Spine aims to develop a novel multifactorial therapy for spinal cord injury (SCI) conceived as a disruptive platform enabling unprecedented multiscale actuation to drive functional neural repair by more accurately tackling SCI complexity. It originally relies on the pivotal role that mechanotransduction plays in the physiology and physiopathology of tissue and organ functions, never explored before for SCI.
Project Overview
We will develop a 3D bioprinted mesh containing nanocarriers with therapeutic agents acting at two pivotal aspects of neural repair:
- Mechanotransduction
- Inhibitory scarring using gene therapy strategies.
Bioactive nanocarriers will be based on cutting-edge nanoparticles whose release will be electrically triggered on-demand via wireless powering. Such a 3D-theramesh offers a novel and exceptionally robust biomaterial for delivering agents at the lesion, controlling time and dose.
Current Advances
Current advances in SCI therapies focus on:
- Rehabilitation
- Cell transplantation
- Drugs
- Biomaterials
- Electrical stimulation
Although these approaches lead to partial sensory/motor recovery, chronic functional deficits limit daily living activities and shorten life expectancy in SCI patients, as they fail to promote successful axon regeneration at the lesion and restore lost functions.
Multidisciplinary Approach
By a multidisciplinary consortium combining scientific, technological, clinical, and industrial partners enriched by their interdisciplinarity, we envision overcoming the limitations of current technologies. This will be achieved by tackling multiple cellular targets involved in neural regeneration after SCI with a balanced combination of therapeutic interventions able to optimally promote functional recovery.
Potential Impact
These radical science-to-technology breakthroughs could enable, if successful, novel technologies and therapies for SCI and many other neural and non-neural pathologies in which some, but not necessarily all, of these targets are involved.
Gender Dimension
The gender dimension will be implemented by ensuring that findings apply to society as a whole.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 3.537.120 |
| Totale projectbegroting | € 3.537.121 |
Tijdlijn
| Startdatum | 1-1-2023 |
| Einddatum | 31-12-2026 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICASpenvoerder
- SERVICIO DE SALUD DE CASTILLA LA MANCHA
- FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
- UNIVERSIDADE DE COIMBRA
- UNIVERSITE CATHOLIQUE DE LOUVAIN
- BLACK DROP BIODRUCKER GMBH
- ACIB GMBH
Land(en)
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A synaptic mechanogenetic technology to repair brain connectivity
Developing a mechanogenetic technology using magnetic nanoparticles to non-invasively regulate neural circuits for treating treatment-resistant brain disorders like stroke and epilepsy.
Smart 4D biodegradable metallic shape-shifting implants for dynamic tissue restoration
BIOMET4D aims to revolutionize reconstructive surgery with shape-morphing implants for dynamic tissue restoration, enhancing regeneration while reducing costs and invasiveness.
Mapping the brain-spinal cord interaction towards understanding and treatment of movement disorders
Move2Treat aims to develop a novel bi-directional brain-spinal cord interface to enhance understanding and treatment of movement disorders through advanced neuronal circuit mapping.
Wireless deep BRAIN STimulation thrOugh engineeRed Multifunctinal nanomaterials
BRAINSTORM aims to develop a scalable wireless neuromodulation technology using smart magnetic nanomaterials to selectively control deep brain neurons for therapeutic applications in Fragile X syndrome.
Advanced Intelligent stimulation device: HAND movement restoration
The AI-HAND project aims to develop an advanced ASIC-based implanted device with self-adapting electrodes to restore hand movements in quadriplegic patients through innovative nerve stimulation techniques.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
A Digitally-Enabled Electroconductive Patient-Specific Stimulation Implant for Spinal Cord InjuryThis project aims to develop a patient-specific 3D-printed neuromodulation implant to enhance neuron regrowth and restore function in spinal cord injury patients through targeted electrical stimulation. | ERC Proof of... | € 150.000 | 2025 | Details |
BRAIN-SPINE INTERFACES TO REVERSE UPPER- AND LOWER-LIMB PARALYSISDeveloping fully-implantable brain-spine interfaces to restore movement in individuals with chronic paralysis through advanced neurosensors and neurostimulation systems. | EIC Transition | € 2.490.802 | 2022 | Details |
DRUG-ELUTING ELECTRICAL IMPLANT TO REPAIR THE SPINAL CORDDREIMS aims to advance a novel drug-eluting electrical implant for spinal cord repair by refining its design and meeting regulatory standards for human therapeutic use. | EIC Transition | € 2.494.542 | 2023 | Details |
Piezoceutical biomaterial scaffolds for immunomodulatory-based myocardial repairThe PiezoMac patch aims to regenerate cardiac muscle post-myocardial infarction using optimized piezoelectric stimulation and 3D-printed designs tailored to patient-specific heart anatomy. | ERC Consolid... | € 2.579.608 | 2024 | Details |
5D Electro-Mechanical Bio-Interface for Neuronal Tissue EngineeringDevelop a novel 3D biomaterial for leadless electrical and mechanical modulation to enhance brain research and neuroengineering applications. | ERC Starting... | € 1.750.000 | 2024 | Details |
A Digitally-Enabled Electroconductive Patient-Specific Stimulation Implant for Spinal Cord Injury
This project aims to develop a patient-specific 3D-printed neuromodulation implant to enhance neuron regrowth and restore function in spinal cord injury patients through targeted electrical stimulation.
BRAIN-SPINE INTERFACES TO REVERSE UPPER- AND LOWER-LIMB PARALYSIS
Developing fully-implantable brain-spine interfaces to restore movement in individuals with chronic paralysis through advanced neurosensors and neurostimulation systems.
DRUG-ELUTING ELECTRICAL IMPLANT TO REPAIR THE SPINAL CORD
DREIMS aims to advance a novel drug-eluting electrical implant for spinal cord repair by refining its design and meeting regulatory standards for human therapeutic use.
Piezoceutical biomaterial scaffolds for immunomodulatory-based myocardial repair
The PiezoMac patch aims to regenerate cardiac muscle post-myocardial infarction using optimized piezoelectric stimulation and 3D-printed designs tailored to patient-specific heart anatomy.
5D Electro-Mechanical Bio-Interface for Neuronal Tissue Engineering
Develop a novel 3D biomaterial for leadless electrical and mechanical modulation to enhance brain research and neuroengineering applications.