SubsidieMeestersMAGNETIC HYPERTHERMIA FOR METASTASIZED TUMOR TREATMENT AND REMOTE MANIPULATION OF MICRODEVICES
The GIULIa project aims to enhance cancer treatment by using magnetic nanoparticles in natural killer cells for targeted hyperthermia and developing magnetic microdevices for precise drug delivery.
Projectdetails
Introduction
In magnetic hyperthermia (MHT), magnetic nanoparticles (MNPs) convert magneto-energy into heat under a time-varying magnetic field. MHT with MNPs is used in catalysis to promote reactions in solution and in cancer therapy, to ‘burn’ primary tumors in clinic, e.g. Glioblastoma, upon deposition of nanoparticles at the tumor site.
Potential of MHT
The power of MHT, being an externally triggered approach to produce heat, goes beyond these actual uses. In the GIULIa project, I will apply MHT in tasks not yet explored to target the unmet needs of treatment of metastasized tumors and address MHT-mediated locomotion.
Challenges in Current Treatments
MHT treatment of cancer metastases is now not doable because of scarce MNP dose accumulation at the spreading tumor sites. In GIULIa, MNPs designed for MHT will be loaded in/on natural killer (NK) immune cells, which, when intravenously injected, will deliver as Trojan horses the right dose of magnetic materials needed for MHT to the metastases.
Enhancing Immune Cell Capability
I will aim at raising the capability of NK and CAR-NK immune cells to infiltrate and recognize the tumor. This will merge synergistic toxic effects of NK cells immunotherapy with MHT-heat damage of MNPs.
Technological Innovations
Next, magnetic microdevices and their remote locomotion based on MHT-heat gradient represent a new technological solution for delivery purposes with no tissue-depth attenuation for their actuation.
Exploration of Heat Localization
Under MHT, I will explore the localization of heat spots on metallic magnetic-based heterostructures as a means to generate bubbles in a liquid and drag an ad hoc designed magnetic microdevice to which the heterostructures are anchored.
Scale-up Synthesis
For the scale-up synthesis of metallic-magnetic heterostructures needed for the microdevices, I will merge an in-flow approach to an MHT-route synthesis. The heat at the MNP surface will be used as an in situ energy source to promote the growth of the metallic domain on the MNP.
Impact of GIULIa
Advanced NK cells and microdevice technology of GIULIa will impact the medical fields of MNP/drug delivery, immunotherapy, and smart robotics.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.993.750 |
| Totale projectbegroting | € 2.993.750 |
Tijdlijn
| Startdatum | 1-2-2023 |
| Einddatum | 31-1-2028 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIApenvoerder
Land(en)
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