Circadian rhythm: from preclinical to post-diagnosis dementia
The RHYTHM IN DEMENTIA project aims to identify circadian rhythm features linked to dementia risk and progression, using accelerometry and biomarkers to inform prevention strategies.
Projectdetails
Introduction
Circadian rhythm (CR) regulates body functions over the 24-hour day/night period; the sleep/wake cycle is its most visible manifestation. CR disruptions have long been observed in patients with dementia, and emerging evidence points to their presence in the preclinical period of dementia. This suggests that certain aspects of CR could be useful in the identification of high-risk individuals and could serve as potential targets for interventions to delay dementia onset and progression.
Importance of Understanding CR in Dementia
This requires an in-depth understanding of the role of CR in dementia pathogenesis. As population aging increases the dementia burden, it is critical to find strategies to identify patients at risk of dementia with precision, prevent, and slow its progression.
Project Overview
Building on recent advances in accelerometry (to assess CR features comprehensively) and dementia biomarkers (deep-phenotyping of dementia pathogenesis), RHYTHM IN DEMENTIA will make a decisive step-change in knowledge by determining CR features involved in dementia processes along the course of the disease.
Project Aims
The aims are:
- Identify core CR features that shape the 10-year risk of dementia in a community-dwelling cohort of 4000 older adults.
- Uncover specific CR disruptions that characterize major dementia subtypes and stages of Alzheimer’s disease (determined by biomarkers) in a new cohort of 1500 patients recruited from two memory clinics in Paris.
- Ascertain how CR affects dementia prognosis in the patient cohort by examining cognitive and functional decline, hospitalization, institutionalization, and mortality.
Expected Outcomes
This project will yield new insight into the nature of the association between CR and dementia progression. These findings will ultimately inform the potential for a cost-effective and easy-to-use tool to assess CR features to facilitate both the identification of patients at risk of dementia and tailored secondary prevention interventions that address CR disruptions in dementia patients and slow the progression of dementia.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 1.999.982 |
Totale projectbegroting | € 1.999.982 |
Tijdlijn
Startdatum | 1-5-2023 |
Einddatum | 30-4-2028 |
Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEpenvoerder
- ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
Land(en)
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This project aims to identify and mitigate health risks associated with disrupted circadian rhythms in night workers through genetic profiling and targeted interventions for healthier aging.
Pre-commercialization of circadian clock-drug interactions screening tool for therapeutic applications
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