SubsidieMeestersNon-invasive patterned electrical neurostimulation of the retina
This project aims to develop non-invasive trans-orbital stimulation techniques and bi-directional interfaces for retinal neurostimulation to enhance artificial vision in patients with retinal degenerative diseases.
Projectdetails
Introduction
Retinal implants remain one of the most demanding technologies in brain-machine interfacing. State-of-the-art devices have yet to reach the needed performances.
Challenges
The main barriers are:
- Sub-optimal stimulation parameters
- Long development and testing procedures
While invasive approaches have yet to achieve the resolution performances needed by millions of patients blinded by retinal degenerative diseases, non-invasive approaches in the form of trans-orbital stimulation have received no attention. Yet, they offer potentially dramatically cheaper and easier to adapt and optimize technology.
Project Goals
The main goal of this project is to advance the field of retina neurostimulation by developing new tools for the study and interfacing with the retina. In particular, we will explore:
- Bi-directional electrophysiological interface which can record and stimulate the intact retina (in the eye)
- Soft multi-electrode arrays for non-invasive stimulation of the retina (soft trans-orbital electrodes)
Methodology
We will use these tools to study the retina in its intact form (in animal models) and implement the gained know-how in humans to study non-invasive stimulation.
Platform Establishment
In this project, we will establish a new platform for bi-directional electrophysiological interfacing with the intact retina and use it to study the retina in its intact form. Such investigations have groundbreaking nature as they can advance both the fundamental understanding of the retina and improve the manner by which we stimulate the retina to generate artificial vision.
Specific Aims
Specifically, we aim to:
- Record spontaneous wave activity and light-sensitive ganglion cells
- Optimize electrical stimulation parameters in the intact retina
- Measure retina responses to trans-orbit stimulation
Ultimate Goal
As the ultimate goal of the project, we aim to establish the foundation of trans-orbital stimulation as a new non-invasive paradigm for functional vision in patients suffering from retinal degenerative diseases.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.500.000 |
| Totale projectbegroting | € 2.500.000 |
Tijdlijn
| Startdatum | 1-4-2023 |
| Einddatum | 31-3-2028 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- TEL AVIV UNIVERSITYpenvoerder
Land(en)
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|---|---|---|---|---|
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Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Inducing functionality in retinal organoids with electrical activities derived from developing retinaThis project aims to enhance the functionality of retinal organoids by using electrophysiological insights from mouse retina development and mathematical models to induce naturalistic electrical features. | ERC STG | € 1.498.364 | 2023 | Details |
Retinal Mesh OptoelectronicsThe project aims to develop a novel Retinal Mesh Optoelectronics using quantum dots and nanowires for flexible, high-density implants to restore vision in patients with photoreceptor degeneration. | ERC COG | € 2.000.000 | 2022 | Details |
Optical imaging platform for high-throughput longitudinal studies of the eye in disease modelsThe OPTIMEYEZ project aims to enhance a novel multi-contrast optical imaging platform for non-invasive retinal studies, facilitating drug development in neurological diseases while reducing animal use. | ERC POC | € 150.000 | 2023 | Details |
High-dimensional electrical stimulation for visual prosthesisThe project aims to enhance visual prostheses by developing sophisticated stimulation protocols for existing microelectrodes, achieving a 20X improvement in spatial resolution to restore vision in blind patients. | EIC Pathfinder | € 2.105.228 | 2022 | Details |
Inducing functionality in retinal organoids with electrical activities derived from developing retina
This project aims to enhance the functionality of retinal organoids by using electrophysiological insights from mouse retina development and mathematical models to induce naturalistic electrical features.
Retinal Mesh Optoelectronics
The project aims to develop a novel Retinal Mesh Optoelectronics using quantum dots and nanowires for flexible, high-density implants to restore vision in patients with photoreceptor degeneration.
Optical imaging platform for high-throughput longitudinal studies of the eye in disease models
The OPTIMEYEZ project aims to enhance a novel multi-contrast optical imaging platform for non-invasive retinal studies, facilitating drug development in neurological diseases while reducing animal use.
High-dimensional electrical stimulation for visual prosthesis
The project aims to enhance visual prostheses by developing sophisticated stimulation protocols for existing microelectrodes, achieving a 20X improvement in spatial resolution to restore vision in blind patients.