SubsidieMeestersOrigami Paper-based tecHnology fOr the innovativE aNd sustaInable Organ-on-Chip devices
The PHOENIX-OoC project aims to revolutionize Organ-on-Chip technology by developing origami paper-based devices for cell co-cultures and pharmacological studies, enhancing sustainability and functionality.
Projectdetails
Introduction
Sustainability is one of the most important concepts nowadays, being able to drive activities in several sectors, namely environment preservation, society, and economy. In Analytical Chemistry, the development of sustainable devices was boosted by the introduction of microfluidic paper-based analytical devices (PADs) whose advantages, however, are not only confined to the concept of sustainability.
Advantages of Paper-Based Devices
Indeed, paper as a functional material confers unprecedented features to PADs. However, paper-based devices remain exploited as only analytical tools but have not (yet) been adopted by the Organ-on-Chip (OoC) world.
Project Objective
The objective of the present project proposal is to alter this scenario. In PHOENIX-OoC, we will radically change the OoC field by making use of paper's versatile properties and develop OoC devices using paper in origami configuration. The devices will be used for:
- Cell co-cultures with the aim to better simulate different organ tissues.
- (Bio)sensors integration with the aim of on-site/continuous monitoring of cells' status/response to stimuli.
- Performing accurate pharmacological studies.
New Technology Introduction
The main new idea is the introduction of a technology that can deliver a versatile set of electrochemical devices with new functionalities. It will be possible to create ready-to-use cell culture models for drug screenings in a custom-made manner.
Consortium Collaboration
Because OoC is a complex system with respect to PADs, partners with different and needed skills have been gathered among the most important European scientists/entities in the field required. The PHOENIX-OoC consortium brings together:
- 6 partners
- 4 Universities
- 1 research organization
- 1 industrial partner (1 SME)
These partners are from 5 EU (associated) countries (Italy, Sweden, Spain, Serbia) and 1 non-EU member: Switzerland. They are renowned experts in the world on paper-based biosensors, in vitro/vivo studies, modeling, microfluidics, biomaterials, and joint tissue engineering.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.202.333 |
| Totale projectbegroting | € 2.202.333 |
Tijdlijn
| Startdatum | 1-3-2024 |
| Einddatum | 28-2-2027 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATApenvoerder
- FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
- UPPSALA UNIVERSITET
- UNIVERZITET U NOVOM SADU FAKULTET TEHNICKIH NAUKA
- SENSE4MED S.R.L.
- UNIVERSITAT BASEL
Land(en)
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Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
High Throughput Modelling and Measurement of Human Epithelial Models using Electrospun Conducting Polymers For Unlocking Data-Driven Drug DiscoveryThe project aims to enhance drug discovery by developing simplified Organ on Chip platforms through hydrogel electrospinning, enabling scalable monitoring and integration into industry workflows. | ERC Proof of... | € 150.000 | 2025 | Details |
Paving the way for High-throughput Organoid ENgineering using Integrated acoustiXPHOENIX aims to develop a microfluidic technology for high-throughput generation of vascularized cerebral organoids, enhancing reproducibility and maturation through acoustophoresis and two-photon writing. | ERC Consolid... | € 2.832.500 | 2023 | Details |
Evolving Organs-on-Chip from developmental engineering to “mechanical re-evolution”EvOoC develops smart Organs-on-Chip platforms that utilize mechanical forces and machine learning to enhance tissue regeneration and disease modeling for innovative therapeutic solutions. | ERC Starting... | € 2.430.625 | 2023 | Details |
PRECISIONDit project onderzoekt het gebruik van 3D-printing om de beperkingen van fotolithografie bij de productie van organ-on-chip modellen te overwinnen voor geneesmiddelentests en biologieonderzoek. | Mkb-innovati... | € 20.000 | 2022 | Details |
Organ on a chip platform for drug discoveryBI/OND ontwikkelt innovatieve hardwareoplossingen voor organen op een chip om gepersonaliseerde medicijnen te bevorderen en het gebruik van dieren in pre-klinisch onderzoek te verminderen. | Mkb-innovati... | € 20.000 | 2021 | Details |
High Throughput Modelling and Measurement of Human Epithelial Models using Electrospun Conducting Polymers For Unlocking Data-Driven Drug Discovery
The project aims to enhance drug discovery by developing simplified Organ on Chip platforms through hydrogel electrospinning, enabling scalable monitoring and integration into industry workflows.
Paving the way for High-throughput Organoid ENgineering using Integrated acoustiX
PHOENIX aims to develop a microfluidic technology for high-throughput generation of vascularized cerebral organoids, enhancing reproducibility and maturation through acoustophoresis and two-photon writing.
Evolving Organs-on-Chip from developmental engineering to “mechanical re-evolution”
EvOoC develops smart Organs-on-Chip platforms that utilize mechanical forces and machine learning to enhance tissue regeneration and disease modeling for innovative therapeutic solutions.
PRECISION
Dit project onderzoekt het gebruik van 3D-printing om de beperkingen van fotolithografie bij de productie van organ-on-chip modellen te overwinnen voor geneesmiddelentests en biologieonderzoek.
Organ on a chip platform for drug discovery
BI/OND ontwikkelt innovatieve hardwareoplossingen voor organen op een chip om gepersonaliseerde medicijnen te bevorderen en het gebruik van dieren in pre-klinisch onderzoek te verminderen.