SubsidieMeestersBreaking the penetration limit of microscopy – Photoswitching Optoacoustics
SWOPT aims to revolutionize in vivo imaging by combining optoacoustic imaging and photoswitching to visualize individual cells deep within tissues, enhancing research in life sciences and biomedicine.
Projectdetails
Introduction
SWOPT is a novel imaging technology that will break through the penetration limits of optical microscopy to visualize individual cells and their function in vivo through several millimeters to centimeters of depth.
Technology Overview
SWOPT will exploit:
- Optoacoustic Imaging (OAI): A modality that combines signal generation similar to optical imaging with the whole-animal imaging capability of ultrasound readout.
- Photoswitching: This will resolve signals from single labeled cells from deep within live tissue.
This combination will achieve volume sampling abilities surpassing any optical microscopy by at least three orders of magnitude (> 5 x 5 x 5 mm imaging volume).
Instrumentation Development
SWOPT will develop the necessary breakthrough instrumentation and concepts, including:
- Unique multiplexed diode illumination
- Novel ultra-wideband transducer technology
- Dedicated inversion algorithms that incorporate photoswitching in the three-dimensional reconstructions
- Uniquely tailored classes of photo-switching transgene and synthetic molecular tools
Proof-of-Concept
The exceptional capabilities of SWOPT will be demonstrated by proof-of-concept work resolving cellular dynamics and functions in a whole tumor in a model of renal cancer in vivo.
Expertise and Collaboration
SWOPT builds on the world-leading expertise in the following disciplines:
- OA imaging technology (Ntziachristos GER)
- Applied mathematics (Unser CH)
- Cancer metabolism (Frezza UK)
The project is driven by excellent young researchers in:
- Protein-engineering (Stiel GER)
- Chemical synthesis (Szymanski NL)
Additionally, it is supported by the science-to-technology focus of ambitious high-tech SMEs (Sonaxis FRA, iThera GER).
Future Aspirations
SWOPT's uniquely comprehensive, yet detailed imaging will enable examination of whole tissues in vivo with the same ease, flexibility, and, eventually, abundance of tools paralleling fluorescence microscopy. This advancement aims to bring research and understanding of living organisms to the next level.
As an affordable imaging technology, SWOPT aspires to become routine in life science and bio-medical research.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 3.536.935 |
| Totale projectbegroting | € 3.536.935 |
Tijdlijn
| Startdatum | 1-9-2022 |
| Einddatum | 31-8-2026 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBHpenvoerder
- SONAXIS
- ACADEMISCH ZIEKENHUIS GRONINGEN
- KLINIKUM DER UNIVERSITAET ZU KOELN
- ITHERA MEDICAL GMBH
- IDRYMA TECHNOLOGIAS KAI EREVNAS
- ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Land(en)
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