SubsidieMeestersK-edge imaging for cOLOR Spectral Photon-Counting Computed Tomography in lung diseases IMAGING
Develop a framework for spectral photon-counting CT Color K-edge imaging to enhance specific and quantitative lung disease diagnostics using nanobiotechnology-based contrast agents.
Projectdetails
Introduction
Computed tomography (CT) is the mainstay of lung imaging because of its higher spatial resolution, convenience, availability, and faster time of acquisition in comparison with other imaging methods such as magnetic resonance imaging (MRI) and nuclear imaging. However, CT’s lack of specificity and absolute quantitative capabilities limits the comprehensive guidance of therapeutic strategies based on imaging assessment of oncologic, inflammatory, and fibrotic pathophysiology processes.
Emerging Technology
Spectral photon-counting CT is an emerging CT technology that not only capitalizes on all CT’s advantages but also offers a cutting-edge method of imaging, called Color K-edge imaging.
Benefits of Color K-edge Imaging
This method allows the specific and quantitative identification of one or multiple atoms concomitantly within a tissue, enabling the simultaneous imaging of independent or interacting pathways.
Limitations
However, K-edge imaging is still limited by its low sensitivity and the scarce availability of contrast agents for potential human translation, and therefore has not been translated yet to practice. Addressing these issues would be extremely beneficial to the diagnostic and theragnostic evaluation of lung diseases in general and more specifically, lung fibrosis and cancer.
Proposal Goals
Therefore, the goal of this proposal is to develop a framework of SPCCT Color K-edge imaging to provide high-resolution specific and quantitative imaging for non-targeting and targeting agents’ candidates, mainly from the nanobiotechnology field.
Preclinical Studies
We will carry out preclinical studies to evaluate the contribution in combination with the contrast agents using different routes of injection, either by:
- Intravenous injection
- Inhalation
Key Applications
This will open the door to the concomitant imaging of lung ventilation and perfusion for monitoring the inflammation and pulmonary agent delivery in animal models.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.603.750 |
| Totale projectbegroting | € 1.603.750 |
Tijdlijn
| Startdatum | 1-4-2024 |
| Einddatum | 31-3-2029 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- UNIVERSITE LYON 1 CLAUDE BERNARDpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
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MANUNKIND: Determinants and Dynamics of Collaborative Exploitation
This project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery.
Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressure
The UnderPressure project aims to investigate how mechanical constraints from 3D crowding affect cell proliferation and signaling in various organisms, with potential applications in reducing cancer chemoresistance.
The Ethics of Loneliness and Sociability
This project aims to develop a normative theory of loneliness by analyzing ethical responsibilities of individuals and societies to prevent and alleviate loneliness, establishing a new philosophical sub-field.
Uncovering the mechanisms of action of an antiviral bacterium
This project aims to uncover the mechanisms behind Wolbachia's antiviral protection in insects and develop tools for studying symbiont gene function.
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MONOBREAST aims to enhance breast cancer imaging by integrating new monochromatic x-ray sources with advanced reconstruction methods to reduce radiation dose and improve diagnostic accuracy.
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