SubsidieMeestersCorrecting for self: The impact of head motion on visual processing and behaviour.
This project aims to uncover the neuronal circuits connecting the vestibular system to visual processing in mice, enhancing understanding of sensory integration during self-motion.
Projectdetails
Introduction
An organism’s survival depends on accurately perceiving and interpreting the environment. A significant part of our visual stimulations is, however, generated by our own actions, rather than external events. For example, the retina can experience similar visual stimuli driven by head movement or by a moving object.
Importance of Self-Motion Information
Therefore, self-motion related information is fundamental to contextualize visual stimuli. In other words, what the eye sees may not be what our brain perceives depending on our actions. In mammals, the vestibular system reports both the motion and orientation of the head.
Knowledge Gaps
Very little is known about the pathways connecting the vestibular system to visual cortical areas, and how this signal is integrated with external visual stimuli to ultimately impact behaviour.
Project Goals
The goal of this project is to unravel the neuronal circuits underlying visual processing during self-motion in mice, thereby providing new insights into sensory processing. To this aim, I will address the following questions:
- What is the long-range and local connectivity of neurons modulated by head rotation in V1?
- What are the circuit mechanisms and neuronal computations involved in the integration of self-motion related signals with visual inputs in V1?
- How do head motion inputs to V1 influence visually-guided actions during behaviour?
Methodology
Achieving these goals relies on a multidisciplinary experimental strategy based on cutting-edge approaches to monitor and control circuit activity with high spatio-temporal resolution in a cell-type specific manner, neuroanatomical tracing, and computational modelling.
Unique Opportunity
This experimental strategy, combined with my research background in visual and vestibular systems, provides a unique opportunity to understand unexplored aspects of sensory processing, at both the cellular and systems levels.
Conclusion
Altogether, this project will reveal a novel framework to understand how sensory processing operates during self-motion to guide behaviour.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.499.639 |
| Totale projectbegroting | € 1.499.639 |
Tijdlijn
| Startdatum | 1-1-2024 |
| Einddatum | 31-12-2028 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRSpenvoerder
Land(en)
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