Adaptive Separation using Dynamic Nanofibril Networks

Introduction

This research program will develop materials, methods, and technologies that enable adaptive separation of molecules and particles using dynamic nanofibril networks. The ground-breaking nature is the development of dynamically tunable membranes/gels for next-generation separation technology.

Current Separation Technologies

Current separation technologies are based primarily on polymeric membranes or gels for membrane filtration or chromatography.

• Membrane filtration is versatile but lacks selectivity.
• Chromatography is selective but has limited throughput.

As pharmaceutical companies move toward protein or nanoparticle-based therapies, the size limitation of chromatography is a concern. The future separation technology should be adaptive and selective, with high resolution and throughput. It is time to develop next-generation separation technology that enables dynamic adaptability and integration with our electronic infrastructure and AI technology.

Nanofibril Networks

Hydrated nanofibril networks with unique nanomechanical behavior, a vast dynamic density range, and large pore sizes enable tunability that polymer networks cannot achieve.

• It is an unexplored class of materials for separation purposes, now available at scale due to recent cellulose and amyloid nanofibril developments.
• Nanofibrils assemble in anisotropic hydrogel networks with uniaxial swelling, ranging from 0 to 1000 g/g water content with pore sizes from a few to 1000 nm.

Research Focus

I will study how different pretreatments or stimuli, such as electrochemistry, enable direct control of this 1000-fold change in pore size, which is unachievable for polymers.

I will explore different modes of separation:

1. Centrifugation
2. Filtration
3. Electro-filtration
4. Ion-selectivity

Using nanofibril networks as an adaptive mesh to sieve/repel molecules and particles of different sizes and charges, the outcome is a scientific foundation exploring how low-density nanofibril networks can lead to disruptive separation technology in a multi-billion-dollar industry.