SubsidieMeestersVersatile Polypeptide-based Intranasal Drug Delivery Platform(s) to Tackle CNS Disorders.
POLYBRAINT aims to develop an innovative intranasal drug delivery platform to effectively transport biological agents across the blood-brain barrier for treating CNS disorders.
Projectdetails
Introduction
Nearly one in six of the world's population suffers from neurological disorders, and this number is expected to keep growing. Many of those central nervous system (CNS) disorders still do not have an approved therapy, mainly due to one of the most challenging barriers, the blood-brain barrier (BBB).
Challenges in Drug Delivery
Only 2% of small-molecule drugs and ~0% of biologic drugs can reach the brain, thus stunting the development of treatment options.
Project Overview
In POLYBRAINT, we will explore the technical and commercial feasibility of an intranasal drug delivery platform (derived from ERC consolidator MyNano) to deliver biological agents to the brain for the treatment of CNS pathologies.
Functionalization and Delivery
After adequate functionalization, our intranasally (i.n.) administered nanocarrier can reach the brain and diffuse through to specific areas of interest (i.e., hippocampus, olfactory bulb...).
Objectives
POLYBRAINT aims to:
- Confirm the transport, delivery, and controlled release of a functional biological agent.
- Establish an intellectual property strategy.
- Assess the future commercialization feasibility of our innovative platform.
Unique Properties of the Platform
Our i.n. platform has unique properties capable of overcoming the main limitations of existing approaches. It can revolutionize what has been achieved so far in the field, including:
- Greater versatility
- Higher loading capacity
- Controlled-sustained drug release after rationally designed bioresponsive conjugation strategies
Scalability and Business Case
Additionally, our nanocarrier can be scaled at the industrial level, thus overcoming a significant bottleneck of current nanocarrier-based therapeutics.
Our platform offers a highly attractive business case, as biotechnology and pharmaceutical companies heavily invest in nanomedicine due to the need for novel drug delivery strategies that can cross challenging biological barriers such as the blood-brain barrier.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-6-2022 |
| Einddatum | 30-11-2023 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPEpenvoerder
Land(en)
Geen landeninformatie beschikbaar
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