SubsidieMeestersTargeted Respiratory Drug Delivery by Tribo Charged Sprays
Develop a new technology for precise drug delivery to the lungs using charged droplets to prevent coalescence, enhancing treatment efficacy for conditions like lung cancer and COVID-19.
Projectdetails
Introduction
The main purpose of this proposal is to develop a radically new technology for very precisely delivering medicine to the human body. Targeted deposition of drug formulations to the lungs exhibits great promise in several treatments, e.g. siRNA treatment against lung cancer or mRNA vaccination against COVID-19.
Current Challenges
This requires oral and nasal inhalation for which spray pumps and nebulizers are widely used to transform an aqueous formulation into a soft mist spray. However, producing the necessary drop size is hampered by droplet coalescence, making drops too large and polydisperse; because of this, they deposit in the wrong places.
Droplet Size and Deposition
- Large droplets between 10 and 50 micrometers deposit mostly in the upper respiratory tract (mouth, throat, or nasal cavity) through ballistic impact on the mucosal tissue.
- Small droplets between 5 and 10 micrometers can be lifted by the airstreams and deposit mostly in the lower respiratory tract (bronchi and lungs).
Our Innovation
Our innovation relies on the charging of drops through the friction with the nozzle material. The charged drops repel and do not coalesce, allowing precise control of their size to target e.g. the lungs.
Conclusion
This allows us to achieve safe and effective targeted deposition of drugs and/or vaccines with hitherto unequaled precision.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-1-2024 |
| Einddatum | 30-6-2025 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- UNIVERSITEIT VAN AMSTERDAMpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
MANUNKIND: Determinants and Dynamics of Collaborative ExploitationThis project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery. | ERC STG | € 1.497.749 | 2022 | Details |
Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressureThe UnderPressure project aims to investigate how mechanical constraints from 3D crowding affect cell proliferation and signaling in various organisms, with potential applications in reducing cancer chemoresistance. | ERC STG | € 1.498.280 | 2022 | Details |
Uncovering the mechanisms of action of an antiviral bacteriumThis project aims to uncover the mechanisms behind Wolbachia's antiviral protection in insects and develop tools for studying symbiont gene function. | ERC STG | € 1.500.000 | 2023 | Details |
The Ethics of Loneliness and SociabilityThis project aims to develop a normative theory of loneliness by analyzing ethical responsibilities of individuals and societies to prevent and alleviate loneliness, establishing a new philosophical sub-field. | ERC STG | € 1.025.860 | 2023 | Details |
MANUNKIND: Determinants and Dynamics of Collaborative Exploitation
This project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery.
Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressure
The UnderPressure project aims to investigate how mechanical constraints from 3D crowding affect cell proliferation and signaling in various organisms, with potential applications in reducing cancer chemoresistance.
Uncovering the mechanisms of action of an antiviral bacterium
This project aims to uncover the mechanisms behind Wolbachia's antiviral protection in insects and develop tools for studying symbiont gene function.
The Ethics of Loneliness and Sociability
This project aims to develop a normative theory of loneliness by analyzing ethical responsibilities of individuals and societies to prevent and alleviate loneliness, establishing a new philosophical sub-field.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Rational and Simulation-Supported Design of Inhalable RNA NanocarrierRatInhalRNA aims to design and optimize biocompatible siRNA nanoparticles for pulmonary delivery using a combination of DoE, MD simulations, and ML to enhance gene silencing efficacy. | ERC COG | € 2.000.000 | 2023 | Details |
Precision Rayleigh jet spraysThis project aims to develop novel spray nozzles that produce perfectly monodisperse sprays by controlling instabilities through advanced hydrodynamics and nanofabrication, enhancing applications in medicine and agriculture. | ERC ADG | € 2.500.000 | 2025 | Details |
Onderzoek naar het toedienen van antivirale formuleringen middels spray nozzletechnologie geïntegreerd in een neusspray ter preventie van respiratoire infectiesHet project onderzoekt de technische en economische haalbaarheid van een short fatty acid-neusspray als antivirale bescherming met optimale verneveling en kostprijsanalyse. | MIT Haalbaarheid | € 20.000 | 2023 | Details |
FIBAIR - Inhalation spray nozzles with improved air mixing for lung fibrosisHet project ontwikkelt nieuwe mixkamer-technologie voor inhalatoren om de behandeling van longfibrose bij (ex-)COVID-19-patiënten te verbeteren en de levensverwachting te verhogen. | MIT R&D Samenwerking | € 270.891 | 2020 | Details |
Rational and Simulation-Supported Design of Inhalable RNA Nanocarrier
RatInhalRNA aims to design and optimize biocompatible siRNA nanoparticles for pulmonary delivery using a combination of DoE, MD simulations, and ML to enhance gene silencing efficacy.
Precision Rayleigh jet sprays
This project aims to develop novel spray nozzles that produce perfectly monodisperse sprays by controlling instabilities through advanced hydrodynamics and nanofabrication, enhancing applications in medicine and agriculture.
Onderzoek naar het toedienen van antivirale formuleringen middels spray nozzletechnologie geïntegreerd in een neusspray ter preventie van respiratoire infecties
Het project onderzoekt de technische en economische haalbaarheid van een short fatty acid-neusspray als antivirale bescherming met optimale verneveling en kostprijsanalyse.
FIBAIR - Inhalation spray nozzles with improved air mixing for lung fibrosis
Het project ontwikkelt nieuwe mixkamer-technologie voor inhalatoren om de behandeling van longfibrose bij (ex-)COVID-19-patiënten te verbeteren en de levensverwachting te verhogen.