SubsidieMeestersSperm filtration for improved success rate of assisted reproduction technology
The 3D nanoMorph project enhances sperm selection for assisted reproduction technologies by enabling detailed analysis of motility and kinematics, addressing fertility challenges in an aging population.
Projectdetails
Introduction
ERC starting grant 3D nanoMorph has achieved groundbreaking results that open an unprecedented opportunity for assisted reproduction technologies (ARTs). ARTs require selecting sperms with high fertilization potential - this is characterized by morphology, motility, and kinematic parameters of sperms indicating their progressive motility.
Current Limitations
Current optical solutions for sperm selection can investigate only:
- Morphology
- Nature of motility
- Kinematics in terms of speed
Innovative Solution
Our groundbreaking solution enables studying the motion of sperm with unprecedented super-resolved details, which can be used to derive advanced kinematic features.
Market Context
The ART market is growing at an annual rate of 7.8%.
Societal Challenges
- Our population is aging.
- People are planning families at later ages.
- Fertility is deteriorating due to occupational, environmental, and lifestyle factors.
Thus, it is becoming a societal challenge to maintain population growth.
Objective
This PoC grant aims to take the next step in transforming my groundbreaking research into innovation of commercial and societal value.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-8-2023 |
| Einddatum | 31-1-2025 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITETpenvoerder
- NORINNOVA AS
Land(en)
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|---|---|---|---|---|
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MANUNKIND: Determinants and Dynamics of Collaborative Exploitation
This project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery.
Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressure
The UnderPressure project aims to investigate how mechanical constraints from 3D crowding affect cell proliferation and signaling in various organisms, with potential applications in reducing cancer chemoresistance.
Uncovering the mechanisms of action of an antiviral bacterium
This project aims to uncover the mechanisms behind Wolbachia's antiviral protection in insects and develop tools for studying symbiont gene function.
The Ethics of Loneliness and Sociability
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Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Mechanism of vertebrate sperm-egg recognition and fusionThis project aims to elucidate the molecular mechanisms of sperm-egg recognition and fusion in vertebrates using zebrafish, with the goal of reconstituting a functional fertilization interface in vitro. | ERC COG | € 2.000.000 | 2023 | Details |
Representative, Reliable and Reproducible in vitro Models of the Human TestesThe project aims to develop a reliable preclinical model of human testes using tailored hydrogels to improve male infertility treatments through high-throughput experimentation and automated analysis. | ERC STG | € 1.499.980 | 2022 | Details |
Shaping the future – From spermatids to spermatozoaThe project aims to enhance understanding of sperm cell morphology and motility through advanced imaging techniques, with implications for infertility diagnosis and potential male contraceptive development. | ERC COG | € 1.999.963 | 2023 | Details |
A Novel Approach to New Family-Forms, Assisted Reproductive Technologies and Transnationalism. A multi-sited ethnography: Spain, Denmark, Canada and IsraelThis project aims to explore the impact of assisted reproductive technologies on new family forms and transnationalism across Europe, North America, and the Middle East through multi-sited ethnography. | ERC ADG | € 2.039.969 | 2024 | Details |
Mechanism of vertebrate sperm-egg recognition and fusion
This project aims to elucidate the molecular mechanisms of sperm-egg recognition and fusion in vertebrates using zebrafish, with the goal of reconstituting a functional fertilization interface in vitro.
Representative, Reliable and Reproducible in vitro Models of the Human Testes
The project aims to develop a reliable preclinical model of human testes using tailored hydrogels to improve male infertility treatments through high-throughput experimentation and automated analysis.
Shaping the future – From spermatids to spermatozoa
The project aims to enhance understanding of sperm cell morphology and motility through advanced imaging techniques, with implications for infertility diagnosis and potential male contraceptive development.
A Novel Approach to New Family-Forms, Assisted Reproductive Technologies and Transnationalism. A multi-sited ethnography: Spain, Denmark, Canada and Israel
This project aims to explore the impact of assisted reproductive technologies on new family forms and transnationalism across Europe, North America, and the Middle East through multi-sited ethnography.