SubsidieMeestersSperm filtration for improved success rate of assisted reproduction technology
The 3D nanoMorph project enhances sperm selection for assisted reproduction technologies by enabling detailed analysis of motility and kinematics, addressing fertility challenges in an aging population.
Projectdetails
Introduction
ERC starting grant 3D nanoMorph has achieved groundbreaking results that open an unprecedented opportunity for assisted reproduction technologies (ARTs). ARTs require selecting sperms with high fertilization potential - this is characterized by morphology, motility, and kinematic parameters of sperms indicating their progressive motility.
Current Limitations
Current optical solutions for sperm selection can investigate only morphology, nature of motility, and kinematics in terms of speed.
Innovative Solution
Our groundbreaking solution enables studying the motion of sperm with unprecedented super-resolved details, which can be used to derive advanced kinematic features.
Market Context
The ART market is growing at an annual rate of 7.8%. Our population is aging, people are planning families at later ages, and fertility is deteriorating due to occupational, environmental, and lifestyle factors.
Societal Challenge
Thus, it is becoming a societal challenge to maintain population growth.
Project Objective
This PoC grant aims to take the next step in transforming my groundbreaking research into innovation of commercial and societal value.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-8-2023 |
| Einddatum | 31-1-2025 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITETpenvoerder
- NORINNOVA AS
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Shaping the future – From spermatids to spermatozoaThe project aims to enhance understanding of sperm cell morphology and motility through advanced imaging techniques, with implications for infertility diagnosis and potential male contraceptive development. | ERC Consolid... | € 1.999.963 | 2023 | Details |
A Novel Approach to New Family-Forms, Assisted Reproductive Technologies and Transnationalism. A multi-sited ethnography: Spain, Denmark, Canada and IsraelThis project aims to explore the impact of assisted reproductive technologies on new family forms and transnationalism across Europe, North America, and the Middle East through multi-sited ethnography. | ERC Advanced... | € 2.039.969 | 2024 | Details |
Representative, Reliable and Reproducible in vitro Models of the Human TestesThe project aims to develop a reliable preclinical model of human testes using tailored hydrogels to improve male infertility treatments through high-throughput experimentation and automated analysis. | ERC Starting... | € 1.499.980 | 2022 | Details |
Developing a human-based stem cell model for reproductive toxicityDeveloping a high-throughput human-based assay for male reproductive toxicity to enhance drug safety testing and reduce reliance on animal models. | ERC Proof of... | € 150.000 | 2024 | Details |
Mechanism of vertebrate sperm-egg recognition and fusionThis project aims to elucidate the molecular mechanisms of sperm-egg recognition and fusion in vertebrates using zebrafish, with the goal of reconstituting a functional fertilization interface in vitro. | ERC Consolid... | € 2.000.000 | 2023 | Details |
Shaping the future – From spermatids to spermatozoa
The project aims to enhance understanding of sperm cell morphology and motility through advanced imaging techniques, with implications for infertility diagnosis and potential male contraceptive development.
A Novel Approach to New Family-Forms, Assisted Reproductive Technologies and Transnationalism. A multi-sited ethnography: Spain, Denmark, Canada and Israel
This project aims to explore the impact of assisted reproductive technologies on new family forms and transnationalism across Europe, North America, and the Middle East through multi-sited ethnography.
Representative, Reliable and Reproducible in vitro Models of the Human Testes
The project aims to develop a reliable preclinical model of human testes using tailored hydrogels to improve male infertility treatments through high-throughput experimentation and automated analysis.
Developing a human-based stem cell model for reproductive toxicity
Developing a high-throughput human-based assay for male reproductive toxicity to enhance drug safety testing and reduce reliance on animal models.
Mechanism of vertebrate sperm-egg recognition and fusion
This project aims to elucidate the molecular mechanisms of sperm-egg recognition and fusion in vertebrates using zebrafish, with the goal of reconstituting a functional fertilization interface in vitro.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Cultivating hope one star sperm at a timeSpermotile aims to revolutionize male infertility treatment by providing an automated, AI-driven sperm selection platform that enhances ART success rates and reduces costs for clinics and patients. | EIC Transition | € 2.499.906 | 2025 | Details |
ReceptIVFity 2.0Het project ontwikkelt ReceptIVFity 2.0, een zelftest die het vaginaal microbioom analyseert om de kans op succesvolle embryo-innesteling bij IVF/ICSI te kwantificeren, wat patiënten helpt bij hun vruchtbaarheidstraject. | Mkb-innovati... | € 249.837 | 2022 | Details |
Predictive REagent-Antibody Replacement Technology stage 2-TranslationPRe-ART-2T aims to advance predictive antibody technology to TRL6, replacing low-quality monoclonal antibodies with high-performing synthetic alternatives, and attract ~€20M in investment. | EIC Transition | € 800.000 | 2022 | Details |
3P-Tec - Three-parent breeding technology for plants of the futureThe project aims to develop a revolutionary three-parent breeding technology (3P-Tec) to create climate-resilient crops, enhancing yields and accelerating the commercialization of improved seed varieties. | EIC Transition | € 2.498.828 | 2022 | Details |
Cultivating hope one star sperm at a time
Spermotile aims to revolutionize male infertility treatment by providing an automated, AI-driven sperm selection platform that enhances ART success rates and reduces costs for clinics and patients.
ReceptIVFity 2.0
Het project ontwikkelt ReceptIVFity 2.0, een zelftest die het vaginaal microbioom analyseert om de kans op succesvolle embryo-innesteling bij IVF/ICSI te kwantificeren, wat patiënten helpt bij hun vruchtbaarheidstraject.
Predictive REagent-Antibody Replacement Technology stage 2-Translation
PRe-ART-2T aims to advance predictive antibody technology to TRL6, replacing low-quality monoclonal antibodies with high-performing synthetic alternatives, and attract ~€20M in investment.
3P-Tec - Three-parent breeding technology for plants of the future
The project aims to develop a revolutionary three-parent breeding technology (3P-Tec) to create climate-resilient crops, enhancing yields and accelerating the commercialization of improved seed varieties.