SubsidieMeestersNanoengineered photoactivated drug-free antimicrobial precision treatment for chronic skin wounds
This project aims to validate a drug-free PHOTOCURE wound patch that uses photocatalytic activity to effectively eradicate antibiotic-resistant biofilms in chronic skin infections like diabetic foot ulcers.
Projectdetails
Introduction
Antibiotic-resistant bacterial skin and soft tissue infections (SSTIs) are difficult to diagnose and treat, prolonging hospital stays and lowering quality of life. Chronic wounds harbor antibiotic-resistant microorganisms that form biofilms, leading to conditions like diabetic foot ulcers (DFUs). Approximately 50% of DFUs become infected, making them the most prevalent and costly diabetes complication, with a higher mortality and morbidity risk from lower limb amputation. There is an urgent need to develop effective, localized solutions for treating SSTIs that do not depend on antibiotics, especially against complex biofilms like those occurring in DFU cases.
Project Overview
In this Proof of Concept project, we will evaluate a PHOTOCURE wound patch: a porous nanothin Ag/TiOx film with visible-light photocatalytic activity that produces superoxide radicals to effectively eradicate biofilms in the SSTIs context.
Features of the PHOTOCURE Patch
- The patch boasts enhanced mechanical stability for durability.
- It maintains sustained activity across multiple irradiation cycles, offering a viable option for recurrent treatment.
- The PHOTOCURE patch presents a more efficient drug-free alternative to conventional antibiotic treatments, with reduced adverse effects, addressing the escalating challenges of antibiotic and multidrug resistance.
Validation and Strategy
The project will validate the antimicrobial efficacy of TiOx-polymer nanocomposite patches against both single and multiple-species biofilms relevant to chronic SSTIs, notably DFUs, using ex vivo and in vivo human-relevant models.
Intellectual Property and Market Analysis
Subsequently, we will devise a comprehensive IP strategy, secure initial patents, and conduct thorough market and competitor analyses within the antimicrobial wound care dressing sector.
Business Case Development
Finally, we will outline a detailed business case for advancing the PHOTOCURE prototype to market.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-10-2024 |
| Einddatum | 31-3-2026 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- KAROLINSKA INSTITUTETpenvoerder
- AETHERPHLOX AB
Land(en)
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LeadToTreat aims to develop targeted nano-formulations for treating MRSA infections by co-delivering novel low-drugability compounds and synergistic antibiotic combinations.
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