SubsidieMeestersHigh-Throughput Production of Extracellular Vesicles from Organoids under Rotating Motion
The project aims to develop a streamlined system for high-throughput production of extracellular vesicles (EVs) by integrating controlled cell configurations to enhance therapeutic potential.
Projectdetails
Introduction
Extracellular vesicles (EVs) have emerged as pivotal regulators of both physiological homeostasis and pathological conditions, including cancer and regenerative diseases. They have recently been pinpointed as central effectors in the therapeutic capabilities of their parent cells.
Current Challenges
Nevertheless, the therapeutic market of EVs still has significant potential for further development. Specifically, EV production methods that deliver robust, scalable, and high-yield productions, if possible with the minimum cell material, are still unattainable.
Limitations of Existing Technologies
Besides, existing technologies are not adequately versatile to accommodate different types of producer cells. This is of particular relevance, given that the biological makeup of the EVs, and in turn their therapeutic potential, strongly depend on the state of the parental cells when stimulated.
Project Aim
Here, we aim to integrate tight control of produced cells configuration with high-throughput production of EVs in a streamlined system.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-10-2024 |
| Einddatum | 31-3-2026 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRSpenvoerder
Land(en)
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Reliable and scalable procedures for the isolation and loading of extracellular vesicles
LABORIOUS aims to develop innovative methods for isolating and loading therapeutic agents into exosomes, enhancing their clinical application in various diseases while minimizing membrane damage.
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TOP-EVICARE aims to enhance cardiac repair in heart failure by developing innovative protein loading systems in extracellular vesicles, ensuring effective delivery and commercialization.
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ExoDevo aims to investigate the role of extracellular vesicles in brain development and their impact on neurodevelopmental disorders using advanced multi-omics and imaging techniques.
Scaling up iPSC Expansion and Differentiation using Recombinant Bioemulsions
The project aims to develop scalable, regulatory-compliant bioemulsions using engineered protein nanosheets for efficient iPSC culture and differentiation, enhancing cell manufacturing and biotech market growth.
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Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Geintegreerd systeem voor fractionering karakterisatie en kwantificatie van extracellulaire blaasjes en hun inhoudCelnext Biotechnologies onderzoekt de haalbaarheid van een geïntegreerd microfluidisch systeem met optische biosensoren voor gestandaardiseerde isolatie en analyse van extracellulaire blaasjes (EBs). | Mkb-innovati... | € 20.000 | 2021 | Details |
TowArd demoCRatization Of ev-BAsed TherapiesEVerZom aims to revolutionize EV manufacturing with a patented scalable process, targeting GMP compliance and commercial production to lead the European market in clinical applications. | EIC Accelerator | € 1.700.000 | 2022 | Details |
Extracellular Vesicles Fiber Optic Surface Plasmon Resonance selection and analysisFOX has developed an automated, label-free fiber-optic technology for rapid, precise purification and quantification of extracellular vesicles directly from crude samples, enhancing diagnostics and R&D. | EIC Accelerator | € 2.499.999 | 2023 | Details |
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automated in-line separatioN and dEtection of eXtracellular vesicles for liqUid biopsy applicationSThe NEXUS project aims to industrialize a customizable platform for the separation and analysis of extracellular vesicles from biofluids, enhancing cancer diagnostics and monitoring. | EIC Transition | € 2.497.750 | 2022 | Details |
Geintegreerd systeem voor fractionering karakterisatie en kwantificatie van extracellulaire blaasjes en hun inhoud
Celnext Biotechnologies onderzoekt de haalbaarheid van een geïntegreerd microfluidisch systeem met optische biosensoren voor gestandaardiseerde isolatie en analyse van extracellulaire blaasjes (EBs).
TowArd demoCRatization Of ev-BAsed Therapies
EVerZom aims to revolutionize EV manufacturing with a patented scalable process, targeting GMP compliance and commercial production to lead the European market in clinical applications.
Extracellular Vesicles Fiber Optic Surface Plasmon Resonance selection and analysis
FOX has developed an automated, label-free fiber-optic technology for rapid, precise purification and quantification of extracellular vesicles directly from crude samples, enhancing diagnostics and R&D.
Exploiting ex vivo expansion and deep multiomics profiling to bring novel, efficient and safer hematopoietic stem cell gene therapies to clinical application
This project aims to innovate hematopoietic stem cell identification and engineering through advanced culture techniques and multiomics profiling, enhancing gene therapy for blood disorders and cancer.
automated in-line separatioN and dEtection of eXtracellular vesicles for liqUid biopsy applicationS
The NEXUS project aims to industrialize a customizable platform for the separation and analysis of extracellular vesicles from biofluids, enhancing cancer diagnostics and monitoring.