SubsidieMeestersDeep Label-Free Cell Imaging of Liquid Biopsies for Cancer Monitoring
Develop and commercialize a label-free interferometric phase microscopy device with AI for cost-effective cancer diagnosis and monitoring via liquid biopsies.
Projectdetails
Introduction
We will develop and commercialize an innovative device for diagnosis and monitoring of cancer in liquid biopsies based on a label-free interferometric phase microscopy (IPM) unit, coupled with dedicated real-time artificial intelligence (AI) for cell classification.
Objectives
This device will materialize an innovative approach for the much-anticipated imaging flow cytometry, dramatically decreasing its costs and improving patient care by accurate monitoring of cancer in the clinical lab from a simple lab test (liquid biopsy).
Key Aspects
The success of the project is dependent on four high-risk/high-gain aspects:
- Building the first clinical IPM device.
- Designing and manufacturing a disposable microfluidic device for imaging flow cytometry.
- Obtaining high-enough acquisition and processing throughput in imaging flow cytometry of urine samples.
- Training a deep neural network to detect cancer cells based on the information-deep label-free IPM images of cancer cells during flow.
Background
The proposed PoC project stems from my ongoing ERC StG project that focuses on the application of IPM for grading the metastatic potential of cancer cells, as a basic-science research tool.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-1-2023 |
| Einddatum | 31-12-2024 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- TEL AVIV UNIVERSITYpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
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|---|---|---|---|---|
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MANUNKIND: Determinants and Dynamics of Collaborative Exploitation
This project aims to develop a game theoretic framework to analyze the psychological and strategic dynamics of collaborative exploitation, informing policies to combat modern slavery.
Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressure
The UnderPressure project aims to investigate how mechanical constraints from 3D crowding affect cell proliferation and signaling in various organisms, with potential applications in reducing cancer chemoresistance.
Uncovering the mechanisms of action of an antiviral bacterium
This project aims to uncover the mechanisms behind Wolbachia's antiviral protection in insects and develop tools for studying symbiont gene function.
The Ethics of Loneliness and Sociability
This project aims to develop a normative theory of loneliness by analyzing ethical responsibilities of individuals and societies to prevent and alleviate loneliness, establishing a new philosophical sub-field.
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