SubsidieMeestersBioactive Tissue Sealant for Enhanced Wound Repair
BioTisSeal aims to create bioactive tissue sealants using gelatin methacryloyl and aptamers for enhanced wound healing and market readiness, addressing current limitations in wound care.
Projectdetails
Introduction
Wound management is a routine part of medical practices worldwide, and delays in healing cause a significant clinical and economic burden. Current tissue sealant formulations that are used for wound care pose various limitations, including the inability to fill in larger defects and the release of toxic by-products (especially from synthetic polymers).
Limitations of Current Sealants
Additionally, most of the commercial sealants provide no bioactive properties, or at best rely on bulk GF loading for inducing cell infiltration or tissue regeneration. The development of a tunable, bioactive hydrogel-based tissue sealant thus provides an attractive opportunity as cell-instructive substrates for enhanced wound healing.
Project Goals
BioTisSeal aims to develop the technology for fabricating “off-the-shelf” bioactive tissue sealants that can not only help in wound closure (or reduce blood loss) but also stimulate better healing.
Technology Development
BioTisSeal will combine the tunable elasticity and adhesive strength of gelatin methacryloyl (GelMA) pre-polymers with angiogenic growth factor (GF) specific aptamers that are capable of sequestering and concentrating GFs that are already present in the tissue fluid at the wound site.
Controlled Release Mechanism
By coupling this to the controlled release behavior of aptamers, a spatiotemporal control of GF bioavailability is achieved for enhanced wound repair.
Market Translation
BioTisSeal will not only develop the technology to make this possible but will also take vital steps to bring this technology to the market.
- Securing the IP
- Analyzing the market connected to BioTisSeal technology
This will form a fruitful basis for translation.
Advisory Board
The inclusion of both a leading wound care company and a clinician in the advisory board will further ensure that BioTisSeal is optimally geared towards clinical translation.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-6-2022 |
| Einddatum | 30-11-2023 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- UNIVERSITEIT TWENTEpenvoerder
Land(en)
Geen landeninformatie beschikbaar
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