SubsidieMeestersBioactive Tissue Sealant for Enhanced Wound Repair
BioTisSeal aims to create bioactive tissue sealants using gelatin methacryloyl and aptamers for enhanced wound healing and market readiness, addressing current limitations in wound care.
Projectdetails
Introduction
Wound management is a routine part of medical practices worldwide, and delays in healing cause a significant clinical and economic burden. Current tissue sealant formulations that are used for wound care pose various limitations, including the inability to fill in larger defects and the release of toxic by-products (especially from synthetic polymers).
Limitations of Current Sealants
Additionally, most of the commercial sealants provide no bioactive properties or, at best, rely on bulk growth factor (GF) loading for inducing cell infiltration or tissue regeneration.
Opportunity for Development
The development of a tunable, bioactive hydrogel-based tissue sealant thus provides an attractive opportunity as cell-instructive substrates for enhanced wound healing.
Project Overview
BioTisSeal aims to develop the technology for fabricating “off-the-shelf” bioactive tissue sealants that can not only help in wound closure (or reduce blood loss) but also stimulate better healing.
Technology Integration
BioTisSeal will combine the tunable elasticity and adhesive strength of gelatin methacryloyl (GelMA) pre-polymers with angiogenic growth factor (GF) specific aptamers that are capable of sequestering and concentrating GFs that are already present in the tissue fluid at the wound site.
Controlled Release Mechanism
By coupling this to the controlled release behavior of aptamers, a spatiotemporal control of GF bioavailability is achieved for enhanced wound repair.
Market Translation
BioTisSeal will not only develop the technology to make this possible but will also take vital steps to bring this technology to the market.
- Securing the IP
- Analyzing the market connected to BioTisSeal technology
A fruitful basis for translation will be formed.
Advisory Board
The inclusion of both a leading wound care company and a clinician in the advisory board will further ensure that BioTisSeal is optimally geared towards clinical translation.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-6-2022 |
| Einddatum | 30-11-2023 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- UNIVERSITEIT TWENTEpenvoerder
Land(en)
Geen landeninformatie beschikbaar
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Personalised Bioelectronics for Epithelial RepairProBER aims to develop personalized bioelectronic wound dressings using conformal DC electrodes to enhance healing speed and efficiency in chronic wounds, preparing for clinical studies. | ERC Proof of... | € 150.000 | 2023 | Details |
Self-feeding implants to improve and accelerate tissue healing using nutritional nanoparticlesThe NutriBone project aims to develop a patented self-feeding bone implant that enhances long-term viability and reduces failure rates for large bone defects through glycogen-based glucose release. | ERC Proof of... | € 150.000 | 2024 | Details |
Nanoengineered photoactivated drug-free antimicrobial precision treatment for chronic skin woundsThis project aims to validate a drug-free PHOTOCURE wound patch that uses photocatalytic activity to effectively eradicate antibiotic-resistant biofilms in chronic skin infections like diabetic foot ulcers. | ERC Proof of... | € 150.000 | 2024 | Details |
Engineering nanoparticle-polymer interactions to create instructive, tough nanocomposite hydrogels without negatively impacting self-healing behavior for bone tissue regenerationNano4Bone aims to engineer self-healing hydrogels with enhanced mechanical properties and bioactive nanoparticles for effective bone tissue regeneration in osteosarcoma treatment. | ERC Consolid... | € 2.000.000 | 2023 | Details |
Bioactive reinforcing bioink for hybrid bioprinting of implantable boneThe project aims to develop 'BioForceInk,' a bioactive bioink for hybrid 3D bioprinting of vascularized bone implants, enhancing mechanical strength and biological functionality for clinical applications. | ERC Proof of... | € 150.000 | 2024 | Details |
Personalised Bioelectronics for Epithelial Repair
ProBER aims to develop personalized bioelectronic wound dressings using conformal DC electrodes to enhance healing speed and efficiency in chronic wounds, preparing for clinical studies.
Self-feeding implants to improve and accelerate tissue healing using nutritional nanoparticles
The NutriBone project aims to develop a patented self-feeding bone implant that enhances long-term viability and reduces failure rates for large bone defects through glycogen-based glucose release.
Nanoengineered photoactivated drug-free antimicrobial precision treatment for chronic skin wounds
This project aims to validate a drug-free PHOTOCURE wound patch that uses photocatalytic activity to effectively eradicate antibiotic-resistant biofilms in chronic skin infections like diabetic foot ulcers.
Engineering nanoparticle-polymer interactions to create instructive, tough nanocomposite hydrogels without negatively impacting self-healing behavior for bone tissue regeneration
Nano4Bone aims to engineer self-healing hydrogels with enhanced mechanical properties and bioactive nanoparticles for effective bone tissue regeneration in osteosarcoma treatment.
Bioactive reinforcing bioink for hybrid bioprinting of implantable bone
The project aims to develop 'BioForceInk,' a bioactive bioink for hybrid 3D bioprinting of vascularized bone implants, enhancing mechanical strength and biological functionality for clinical applications.
Vergelijkbare projecten uit andere regelingen
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|---|---|---|---|---|
Bio2Skin, the first clinically skin-preserving biomaterial replacing silicones/acrylate as medical skin adhesivesBH4U's Bio2Skin is a revolutionary glueless medical adhesive that minimizes skin injuries from prolonged use, offering a safe, cost-effective solution for external medical devices. | EIC Accelerator | € 2.492.571 | 2024 | Details |
Bacteria Biofilm as bio-factory for tissue regenerationBIOACTION aims to transform biofilm-associated infections into a resource for tissue regeneration using functionalized bio-hydrogels and engineered liposomes, enhancing implant technology and health outcomes. | EIC Pathfinder | € 2.903.862 | 2023 | Details |
Ontwikkeling van een waterdichte, afsluitende patch ter voorkoming van hersenvocht lekkage na neurochirurgische operatiesPolyganics en Elana ontwikkelen een synthetische patch voor een waterdichte sluiting van de dura na neurochirurgie, om complicaties te verminderen en de patiëntkwaliteit te verbeteren. | Mkb-innovati... | € 200.000 | 2015 | Details |
A Paradigm Shift in Health Monitoring with Electrospun Enzymatic NeomaterialsWOUNDSENS aims to develop innovative wearable biosensors integrated into smart wound dressings to enhance chronic wound monitoring and improve patient quality of life. | EIC Pathfinder | € 2.934.318 | 2023 | Details |
Medical nanofiber technology to prevent cerebrospinal leakage in neurosurgeriesNurami's ArtiFix is a revolutionary bio-absorbable patch designed to prevent cerebrospinal fluid leaks post-surgery, improving patient outcomes and reducing healthcare costs. | EIC Accelerator | € 2.495.624 | 2024 | Details |
Bio2Skin, the first clinically skin-preserving biomaterial replacing silicones/acrylate as medical skin adhesives
BH4U's Bio2Skin is a revolutionary glueless medical adhesive that minimizes skin injuries from prolonged use, offering a safe, cost-effective solution for external medical devices.
Bacteria Biofilm as bio-factory for tissue regeneration
BIOACTION aims to transform biofilm-associated infections into a resource for tissue regeneration using functionalized bio-hydrogels and engineered liposomes, enhancing implant technology and health outcomes.
Ontwikkeling van een waterdichte, afsluitende patch ter voorkoming van hersenvocht lekkage na neurochirurgische operaties
Polyganics en Elana ontwikkelen een synthetische patch voor een waterdichte sluiting van de dura na neurochirurgie, om complicaties te verminderen en de patiëntkwaliteit te verbeteren.
A Paradigm Shift in Health Monitoring with Electrospun Enzymatic Neomaterials
WOUNDSENS aims to develop innovative wearable biosensors integrated into smart wound dressings to enhance chronic wound monitoring and improve patient quality of life.
Medical nanofiber technology to prevent cerebrospinal leakage in neurosurgeries
Nurami's ArtiFix is a revolutionary bio-absorbable patch designed to prevent cerebrospinal fluid leaks post-surgery, improving patient outcomes and reducing healthcare costs.