SubsidieMeestersAtlas of the Human Deep Brain Nuclei, Connections, and Vasculature
The project aims to create an atlas of human deep brain nuclei and vasculature to enhance deep-brain stimulation outcomes and minimize side effects in movement and neuropsychiatric disorders.
Projectdetails
Introduction
Deep-brain stimulation, DBS in short, is one of the most promising surgical treatments for movement disorders such as Parkinson’s disease (PD), and more recently, neuropsychiatric diseases such as obsessive-compulsive disorder.
DBS Surgery
During DBS surgery, a microelectrode is lowered deep into the brain with the aim to stimulate small subcortical nuclei in order to alleviate disease-related symptoms such as rigidity and tremor as seen in patients with PD.
Side Effects of DBS
Studies using DBS in PD patients show that a suboptimal placement of electrodes in, for example, the Subthalamic Nucleus (STN) or Globus Pallidus (GP), can yield changes in cognitive processes and affective states. These include:
-
Cognitive processes:
- Attention
- Mental speed
- Response inhibition
-
Affective states:
- Depression
- Hypomania
- Anxiety
- Hypersexuality
- Hallucinations
These unwanted side effects of DBS are speculated to be the result of:
- The stimulation of subareas other than the motor zone within these nuclei
- The stimulation of white matter connections
- The dysregulation of blood flow to neighboring areas
Project Aim
Our aim is to create an atlas of the human Deep Brain nuclei, connections, and vasculature (DeepBrainVascu) to substantially improve the outcome of DBS by significantly reducing unwanted side effects.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 150.000 |
| Totale projectbegroting | € 150.000 |
Tijdlijn
| Startdatum | 1-3-2023 |
| Einddatum | 31-8-2024 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- UNIVERSITEIT VAN AMSTERDAMpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
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|---|---|---|---|---|
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Elucidating the phenotypic convergence of proliferation reduction under growth-induced pressure
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The Ethics of Loneliness and Sociability
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Interrogating basal ganglia reinforcement with deep brain stimulation in Parkinson’s disease.ReinforceBG aims to explore dopamine's role in Parkinson's disease through advanced neuromodulation techniques to enhance understanding and develop innovative treatments for motor and cognitive symptoms. | ERC STG | € 1.499.580 | 2023 | Details |
Bidirectional Brain/Neural-Computer Interaction for Restoration of Mental HealthThis project aims to develop a portable neuromodulation system using quantum sensors and magnetic stimulation to precisely target brain oscillations for treating mental health disorders. | ERC COG | € 1.999.875 | 2025 | Details |
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Interrogating basal ganglia reinforcement with deep brain stimulation in Parkinson’s disease.
ReinforceBG aims to explore dopamine's role in Parkinson's disease through advanced neuromodulation techniques to enhance understanding and develop innovative treatments for motor and cognitive symptoms.
Bidirectional Brain/Neural-Computer Interaction for Restoration of Mental Health
This project aims to develop a portable neuromodulation system using quantum sensors and magnetic stimulation to precisely target brain oscillations for treating mental health disorders.
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Dissecting the biophysical mechanisms of deep brain stimulation using voltage fluorescence microscopy
This project aims to elucidate the cellular mechanisms of deep brain stimulation in epilepsy using a novel optical technique to improve therapeutic protocols for human patients.