SubsidieMeestersMorphogenesis meets Cell Fate: Dissecting how Mechanical Forces coordinate Development
This project aims to explore how mechanical forces influence morphogenesis and cell fate in Xenopus embryos, integrating biophysical methods to enhance understanding of tissue formation.
Projectdetails
Introduction
During embryonic development, an unspecialized cell mass is transformed into complex tissues and organs through collective movements and cell interactions. The acquisition of such structural and functional diversity is powered by two main processes: morphogenesis, which sculpts cells into tissues and organs, and cell fate acquisition, which assigns specific identities to cells.
Research Gap
Despite extensive research, the intricate coordination between these two processes remains elusive. Mechanical forces determine the shape and structure of tissues, and their impact on cell fate has been recently uncovered, emphasizing the significance of mechanics in regulating both morphogenesis and cell fate.
Complexity of the Relationship
However, understanding the relationship between these two processes is complex, as it requires the integration of:
- Cell shape
- Cell behavior
- Mechanics
- Gene expression across the tissue over time.
Project Overview
In this project, we will apply cutting-edge biophysical and data science methods to the mucociliary epithelium of Xenopus embryos to dissect the role of mechanics in both morphogenesis and cell fate acquisition in vivo.
Objectives
We will:
- Determine how cells undergoing fate acquisition trigger local tissue rearrangements that lead to global morphogenetic movements.
- Investigate the impact of tissue mechanics on cell fate and transitions.
- Combine cell behaviors, gene expression, and mechanics into a model to predict cell fate.
Expected Outcomes
By exploring the ways cells respond to and modify their mechanical surroundings and the circumstances in which external forces determine cell fate, we will uncover the basic principles of complex tissue formation. This research will give us a comprehensive understanding of how individual cells, as mechanical elements, interact to form a tissue structure that is more than just the sum of its parts.
Significance
The findings will have a significant impact on other tissues, particularly the human airways, and advance our knowledge of embryonic development.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.000.000 |
| Totale projectbegroting | € 2.000.000 |
Tijdlijn
| Startdatum | 1-3-2024 |
| Einddatum | 28-2-2029 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- KOBENHAVNS UNIVERSITETpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
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Coupling morphogen dynamics with mechanics in the control of form and pattern
This project aims to uncover how morphogen dynamics and mechanical properties interact to coordinate patterning and morphogenesis in zebrafish and human gastruloids, with broader implications for biology and medicine.
Collective Regulation of Cell Decisions
This project aims to explore how collective tissue properties influence cell decisions in zebrafish by manipulating cell parameters to engineer tissue characteristics and uncover developmental mechanisms.
Control mechanisms and robustness of multicellular symmetry breaking
This project aims to uncover the mechanisms of symmetry breaking in early animal development by integrating genetic, biophysical, and synthetic approaches to enhance our understanding of tissue organization.
Physical basis of Collective Mechano-Transduction: Bridging cell decision-making to multicellular self-organisation
This project investigates how mechanical forces in tissue microenvironments influence gene expression and multicellular behavior, aiming to bridge biophysics and biochemistry for improved disease therapies.
Deciphering the role of surface mechanics during cell division
MitoMeChAnics aims to uncover how cell surface mechanics regulate division by using novel molecular tools and interdisciplinary methods to link structure and function at the cellular level.