Modelling Inter-Scale Energetics in GastroIntestinal ElectroMechanics

Introduction

The MiGEM proposal targets one of the remaining grand challenges in biomechanics: the development of a comprehensive, inter-scale, thermodynamically and energetically coherent multiphysics model of gastrointestinal (GI) motility.

Importance of the Project

Despite the importance of gastrointestinal disorders as a primary global health problem, electromechanical modelling of gastrointestinal motility still presents significant theoretical and experimental limitations compared to more advanced fields such as cardiovascular bioengineering.

Technical Challenges

Technical difficulties exist due to:

• The intrinsic multiscale nature of gastrointestinal tissues
• The coupling of multiple cell types and roles
• The combination of electrical and mechanical phenomena involving different energetic mechanisms

Potential Impact

MiGEM has the potential to unlock new frontiers in GI research, addressing several state-of-the-art problems in gastrointestinal motility and opening unprecedented opportunities in novel subject-specific therapies.

Scientific Approach

By adopting a rigorous theoretical-experimental scientific approach, MiGEM will advance state-of-the-art gastrointestinal theoretical modelling and experimental measurements. This will unveil fundamental energetic mechanisms that govern stomach and intestine motility in health and disease.

Innovative Measurements

MiGEM will enable the first calorimetric measurement of tissue samples from the GI tract and create a new path in biomechanical modelling by assimilating innovative data into multiscale thermodynamic models.

Collaboration and Networking

The project will create a new network of scientists with complementary experimental and modelling skills, fostering cross-fertilization, providing senior-to-junior methodological transfer, and supporting gender balance.

Key Elements for Success

The scientific experience of the PI, the formal membership to the project of the ABI, University of Auckland, and the multiple scientific collaborations that the PI has engaged in for many years will be the key elements to successfully carry out an ambitious and high-risk project.