SubsidieMeestersImpact Of The Gut Microbiota On Host Cells Energy Metabolism: Role In Health And In Inflammatory bowel disease
The ENERGISED project aims to explore how altered gut microbiota affects host cell energy metabolism in inflammatory bowel diseases to develop new microbiota-based therapies.
Projectdetails
Introduction
Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are immune-related disorders characterized by inappropriate gut inflammation. Their incidence has increased dramatically in Western countries in recent decades, supporting a role for environmental factors.
Current Challenges
Despite the development of new treatments, IBD are insufficiently controlled in a large proportion of patients, inducing an alteration in quality of life and a socioeconomic burden. A better understanding of the pathogenesis and identification of new therapeutic targets are therefore urgently needed.
Role of Gut Microbiota
In this context, the gut microbiota has been recognized as a strong actor in IBD. Additionally, an alteration in intestinal and immune cell energy metabolism has been suggested in the pathogenesis.
Host-Microbe Interaction
Classical host-microbe interaction concepts rely on the recognition of conserved microbial motifs by innate immunity sensors or on the action of microbial molecules on a host cell receptor. However, energy metabolism plays a crucial role in mounting the appropriate cellular response, and emerging data indicate that the gut microbiota may directly affect it.
Hypothesis
I hypothesize that the altered gut microbiota in IBD contributes to the impairment of host cell energy metabolism and pathogenesis.
Project Aims
The aims of ENERGISED are to:
- Identify the microorganisms and microbiota-derived metabolites impacting host cell energy metabolism and the mechanisms involved.
- Decipher the consequences of gut microbiota alterations on host cell energy metabolism in IBD.
- Design new microbiota-based therapeutic strategies to manipulate the host cell energy state in IBD.
Project Scope
This challenging project involves multidisciplinary aspects from microbiology to immunology, metabolism, and medicine; the use of multiple cutting-edge technologies; and translational analysis from mice to humans.
Societal Impact
In addition to its scientific importance, it will have societal impacts due to the identification of new therapeutic strategies.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.999.265 |
| Totale projectbegroting | € 1.999.265 |
Tijdlijn
| Startdatum | 1-9-2022 |
| Einddatum | 31-8-2027 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- SORBONNE UNIVERSITEpenvoerder
- ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
- INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Land(en)
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