SubsidieMeestersSTEM CELL PLASTICITY IN ADULT NEUROGENIC NICHES
This project aims to uncover the molecular mechanisms of plasticity in adult neural stem cells to enhance understanding of their behavior and potential implications for glioma treatment.
Projectdetails
Introduction
Somatic stem cells (SCs) sustain tissue renewal and regeneration in adult mammals. The maintenance of their stemness and long-lasting preservation in cohabitation with differentiated progeny at specific niches poses these cells to a considerable challenge.
Cellular Plasticity
To deal with it, SCs display a complex network of yet to be fully uncovered mechanisms that allow multilevel plasticity. Cellular plasticity indicates the ability of cells to reversibly change their phenotype in response to the microenvironment.
Neural Stem Cells
In the subependymal zone of the adult rodent brain, self-renewing neural SCs (NSCs) generate new neurons for pre-existing olfactory circuits. It is clear that NSCs must be endowed with plasticity properties, but the analysis of these potential traits needs a precise definition and a combination of comprehensive approaches to unravel their molecular regulation.
Research Objectives
Building from our new technologies and some preliminary data, in this proposal we will try to advance in the molecular basis and extent of the cell plasticity repertoire of adult subependymal NSCs by concentrating on three of its potential forms:
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Epithelial plasticity: The ability to dynamically and reversibly undergo epithelial-to-mesenchymal transitions, a form of cell adaptation that has never been conceptually proposed or evaluated in adult NSCs.
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Cycling plasticity: The ability to move in and out of the cell cycle and remain quiescent for long periods of time. This plasticity clearly exists, but its molecular regulation remains largely elusive.
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Immune plasticity: The capacity to evade adaptive immunity. Our view about immunity in the brain has dramatically changed in the last few years, raising interest in its potential interaction with NSCs.
Implications
Understanding cell plasticity traits in NSCs may contribute to understanding not only NSC and/or SC behavior but also glioma biology and to identify pathways to intervene in brain tumor treatment.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.499.783 |
| Totale projectbegroting | € 2.499.783 |
Tijdlijn
| Startdatum | 1-12-2023 |
| Einddatum | 30-11-2028 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- UNIVERSITAT DE VALENCIApenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Neural Stem Cell Coordination: a Developmental, Evolutionary and Circuit perspectiveThis project aims to explore the molecular and functional diversity of neural stem cells in adult mammalian brain niches to understand their role in neurogenesis and brain plasticity. | ERC Starting... | € 1.497.575 | 2025 | Details |
PErPetuating Stemness: From single-cell analysis to mechanistic spatio-temporal models of neural stem cell dynamicsThis project aims to decode the mechanisms of neural stem cell heterogeneity and behavior through experimental and mathematical approaches, enhancing understanding and manipulation of stemness. | ERC Synergy ... | € 10.858.174 | 2023 | Details |
Enhancing endogenous regenerative response in mammals by redeploying Cranial Neural Crest Cells pluripotency developmental programs and positional identity remodelingThis project aims to investigate the gene regulatory networks and chromatin changes in cranial neural crest cells to understand their pluripotency and potential for craniofacial tissue repair. | ERC Starting... | € 1.497.500 | 2023 | Details |
The Interplay of Aging, Immune Signaling and Stem Cell FunctionThis project aims to investigate how immune environment changes contribute to muscle stem cell dysfunction and regenerative decline in aging, with the goal of improving stem cell therapies. | ERC Consolid... | € 1.998.843 | 2024 | Details |
Stem and niche cell dynamics in normal and pathological conditionsThis project investigates how skeletal muscle stem cells respond to distant pathologies, aiming to uncover new insights into stem cell behavior and tissue regeneration using advanced multiomics and imaging techniques. | ERC Advanced... | € 2.499.600 | 2022 | Details |
Neural Stem Cell Coordination: a Developmental, Evolutionary and Circuit perspective
This project aims to explore the molecular and functional diversity of neural stem cells in adult mammalian brain niches to understand their role in neurogenesis and brain plasticity.
PErPetuating Stemness: From single-cell analysis to mechanistic spatio-temporal models of neural stem cell dynamics
This project aims to decode the mechanisms of neural stem cell heterogeneity and behavior through experimental and mathematical approaches, enhancing understanding and manipulation of stemness.
Enhancing endogenous regenerative response in mammals by redeploying Cranial Neural Crest Cells pluripotency developmental programs and positional identity remodeling
This project aims to investigate the gene regulatory networks and chromatin changes in cranial neural crest cells to understand their pluripotency and potential for craniofacial tissue repair.
The Interplay of Aging, Immune Signaling and Stem Cell Function
This project aims to investigate how immune environment changes contribute to muscle stem cell dysfunction and regenerative decline in aging, with the goal of improving stem cell therapies.
Stem and niche cell dynamics in normal and pathological conditions
This project investigates how skeletal muscle stem cells respond to distant pathologies, aiming to uncover new insights into stem cell behavior and tissue regeneration using advanced multiomics and imaging techniques.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
A multiplexed biomimetic imaging platform for assessing single cell plasticity (Plastomics) and scoring of tumour malignancyThe PLAST_CELL project aims to develop a microfluidics-based imaging platform to quantify cancer cell plasticity, enhancing diagnosis and treatment of metastasis and therapy resistance. | EIC Pathfinder | € 2.982.792 | 2022 | Details |
A multiplexed biomimetic imaging platform for assessing single cell plasticity (Plastomics) and scoring of tumour malignancy
The PLAST_CELL project aims to develop a microfluidics-based imaging platform to quantify cancer cell plasticity, enhancing diagnosis and treatment of metastasis and therapy resistance.