Foldable, REconfigurable & Jagged devices for enhanced drug Absorption/seeding

Introduction

Oral delivery of protein/peptide drugs is extremely challenging, and the majority of research in the field is based on exploring new formulations, for instance, using permeation enhancers. In recent years, some research has been done on ingestible devices for internal injections.

Proposed Approach

Here, I propose an entirely new approach based on what we have named Self-configurable, Proximity Enabling Devices (SPEDs). The idea is that these devices (the simplest ones will be rolled-up foils) will unfold in the gut, embed in the mucus layer, and align to the intestinal wall.

Importance of Proximity

It is essential that the SPED has close proximity to the intestinal wall and is retained for a while in order to ensure efficient drug delivery. The proximity will additionally allow us to study and explore the influence of nanotextures (embedded in the SPED) on the interaction with the intestinal wall as well as micromotor-based delivery.

Specific Objectives

The SPEDs will be developed and characterized with the following specific objectives:

1. Understanding the SPED properties needed to penetrate mucus.
2. Investigating the mechanisms for enhanced retention time.
3. Exploring the SPED as a carrier for self-propelling cargo.
4. Unraveling the overall behavior of SPED.
5. Demonstrating anti-diabetic drug formulation delivery with at least 5% systemic uptake and showing feasibility of a wider range of applications (delivering/seeding e.g., peptide and proteins/vaccines/probiotics).

Methodology

The work will include:

• Simulations of soft materials.
• Device design.
• Micro/nano fabrication.
• Development and use of techniques for mechanical characterization of device/tissue interaction.
• Bioimaging and in vitro and in vivo studies.

Novelty

The major novelty lies in the SPED concept, providing tissue alignment/contact and unidirectional drug release. Further, the SPEDs provide a unique platform for studies on micromotors as well as nanotextures interaction with the epithelium.