SubsidieMeestersBrain fluids - Transport and clearance
The "aCleanBrain" project aims to uncover brain fluid dynamics mechanisms and develop advanced simulation algorithms using machine learning for better understanding of neurodegenerative diseases.
Projectdetails
Introduction
Scientific breakthroughs in neuroscience explain the need for sleep and the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases in terms of fluid dynamics: the waste created during the day is cleared away as we sleep or it accumulates.
Research Background
However, a decade of research after the original theory was posed has revealed that the underlying physical mechanisms are still not understood and that advanced mathematical tools are needed.
Project Proposal
In this project, we propose a research program addressing:
- New fluid dynamics mechanisms
- Novel numerical analysis for advanced multi-physics brain simulations
- A framework for patient-specific simulations
We will exploit reduced order and machine learning methods in addition to finite element solutions.
Expected Outcomes
With successful delivery, the "aCleanBrain" will:
- Establish the main drivers of brain fluid dynamics
- Provide a foundation for accurate, efficient, and robust algorithms for multi-physics problems
- Develop a software framework for advanced biomechanical brain simulations
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.493.750 |
| Totale projectbegroting | € 2.493.750 |
Tijdlijn
| Startdatum | 1-8-2024 |
| Einddatum | 31-7-2029 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- SIMULA RESEARCH LABORATORY ASpenvoerder
Land(en)
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