MIRACLE the platform for virtual biopsies; introducing Metabolic MRI-as-a-Service for oncologic care

MIRACLE aims to develop a non-invasive MRI add-on for virtual biopsies, enabling personalized cancer treatment decisions by providing structural and metabolic tumor information globally.

Subsidie
€ 2.495.127
2022

Projectdetails

Introduction

Imagine a future where the limitless possibilities of virtual biopsies in cancer diagnostics can be explored. A future in which cancer patients would have access to MRI-enabled virtual biopsies in order to receive the best possible treatment decisions anywhere on the globe.

Project Overview

MIRACLE is developing a first-of-its-kind add-on device for MRI scanners that will be used to acquire a virtual biopsy of the tumor. This device will provide not only structural information on tumor dimensions for (tissue-conserving) surgery but also unique metabolic information on the efficacy of specific systemic therapies.

Benefits of the Approach

Ultimately, this fully non-invasive, accurate, and rapid predictive approach can guide patients to the best-fitting treatment plan given their personal circumstances and tumor characteristics.

Collaboration

WaveTronica (WT), together with the University Medical Centre Utrecht (UMCU), German Cancer Research Centre (DKFZ), and Medical University of Lublin (UMLUB), aim to build this future by bringing the first Metabolic MRI-as-a-Service solution to the market.

Previous Research

Past projects and research led to the development of a Proof-of-Concept MRI coil capable of detecting metabolic biomarkers non-invasively using the strongest clinically available MRI system. This was demonstrated in:

  1. FET-OPEN-01-2016-2017-801075 - the Non-Invasive-Chemistry-Imaging (NICI)
  2. FET-OPEN-03-2018-2019-2020 - FET Innovation Launchpad - MIRACLE

Device Specifications

The MRI coil is a plug-and-play add-on for existing MRI machines, resulting in an accessible and affordable virtual biopsy tool that can identify cancer biomarkers and tumor activity without shedding a drop of patient blood.

Project Goals

This project converts a complex research tool into an accessible diagnostic service (Metabolic MRI-as-a-Service). MIRACLE is supported by the Dutch reimbursement company VGZ, Tesla DC, and oncologists, showing there is a strong market demand.

Future Challenges

Now the challenge lies in bringing the breast coil PoC hardware and software to the next level using breast cancer as a use case.

Financiële details & Tijdlijn

Financiële details

Subsidiebedrag€ 2.495.127
Totale projectbegroting€ 2.498.128

Tijdlijn

Startdatum1-5-2022
Einddatum30-4-2025
Subsidiejaar2022

Partners & Locaties

Projectpartners

  • WAVETRONICA BVpenvoerder
  • DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
  • UNIWERSYTET MEDYCZNY W LUBLINIE
  • UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Land(en)

NetherlandsGermanyPoland

Vergelijkbare projecten binnen EIC Transition

EIC Transition

Very High Energy Electrons Beam for Radiotherapy

eBeam4Therapy aims to revolutionize cancer treatment by developing compact, cost-effective VHEE radiotherapy using laser plasma accelerators to improve patient outcomes and reduce side effects.

€ 2.477.043
EIC Transition

High-throughput hyperspectral imaging across the VIS-SWIR spectrum in a single device

The HYPERIA project aims to develop a novel hyperspectral imaging camera using Fourier Transform interferometry for enhanced sensitivity and wavelength range, targeting applications in food safety and waste separation.

€ 1.500.000
EIC Transition

Therapeutic Antisense Oligonucleotides Targeting NUMB Alternative Splicing in Lung Adenocarcinoma

This project aims to develop Antisense Oligonucleotides to correct pathological splicing of the NUMB gene in lung adenocarcinomas, improving treatment efficacy and paving the way for clinical trials.

€ 2.899.553
EIC Transition

Photonic chip based high-throughput, multi-modal and scalable optical nanoscopy platform

NanoVision aims to revolutionize optical nanoscopy with an affordable, compact, and high-throughput photonic-chip solution, enhancing accessibility and flexibility for research and clinical labs.

€ 2.489.571

Vergelijkbare projecten uit andere regelingen

ERC COG

Deuterium labeling of GLUCOse improves magnetic resonance imaging Sensitivity to CANcer metabolism

GLUCO-SCAN aims to develop and clinically evaluate a novel whole-body deuterium metabolic imaging (DMI) method for cancer assessment, overcoming PET's limitations and enabling widespread screening.

€ 2.495.924
ERC STG

Transformative Pediatric Brain Cancer Imaging using Integrated Biophysics-AI Molecular MRI

Develop a novel AI-driven molecular MRI technology for rapid, noninvasive monitoring of pediatric brain cancer treatment response, enhancing precision medicine and understanding of tumor dynamics.

€ 1.497.669
ERC STG

Hyperpolarized Magnetic Resonance at the point-of-care

HYPMET aims to revolutionize personalized cancer treatment by developing a compact NMR technology for real-time monitoring of metabolic pathways and body fluid analyses using enhanced hyperpolarization methods.

€ 1.499.968
ERC STG

Revealing liver micrometastases in vivo using ultra-high definition MRI

MicroMetSCAN aims to revolutionize MRI techniques for early detection of liver micrometastases, enhancing cancer diagnosis and treatment through improved imaging sensitivity and biological insights.

€ 1.998.456