SubsidieMeestersNext Generation 3D Tissue Models: Bio-Hybrid Hierarchical Organoid-Synthetic Tissues (Bio-HhOST) Comprised of Live and Artificial Cells.
Bio-HhOST aims to create bio-hybrid materials with living and artificial cells for dynamic communication, enhancing tissue modeling and reducing animal use in drug research.
Projectdetails
Introduction
Bio-HhOST will build bio-hybrid materials that comprise living and artificial cells, in dynamic communication, such that artificial cells may influence the proliferation, differentiation, and function of living cells. This will be accomplished by producing precision engineered, microscale, liquid and lipid bilayer-based, chemically compartmentalised artificial cells, co-localised with live cells.
Interdisciplinary Team
This will be done by an interdisciplinary team of biologists, engineers, mathematicians, and entrepreneurs. The artificial cells will contain functional metabolisms and the ability to respond to chemical stimuli in the environment to release signaling molecules, on demand, to regulate the neighboring living cells, as found in complex biological tissues.
Paradigm Shift
These new chemically programmable organoid-synthetic tissues will enable a paradigm shift in both the ability to elucidate and control the complexity of physio-chemical interactions within 3D tissues, and reduce animal use in pharmaceutical R&D.
Workplan Overview
To achieve these ambitions, we have designed an integrated multistage workplan driving towards the following overarching aims:
- Aim 1: Create 3D tissues where spatial regulation of living cell differentiation is determined by co-located (chemically programmable) artificial cells.
- Aim 2: Regulate and maintain such 3D tissues by dynamic communication between live and artificial cells.
- Aim 3: Develop multi-level, multi-approach models of organoid-synthetic tissues behavior.
- Aim 4: Evaluate drug delivery vectors for next generation biological therapeutics.
- Aim 5: Generate complex tissues formed of distinct different regions, not achievable with current organoid protocols.
Wider Ambitions
These exemplify our wider ambitions for the Bio-HhOST approach, including to:
i. Understand cell behavior in increasingly realistic 3D tissue models.
ii. Elucidate targets for the treatment of disease.
iii. Enable the reduction of animal use in pharmaceutical research.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.225.468 |
| Totale projectbegroting | € 1.226.718 |
Tijdlijn
| Startdatum | 1-2-2024 |
| Einddatum | 31-1-2027 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- UNIVERSITA DEGLI STUDI DI TRENTOpenvoerder
- ELVESYS
- HMU HEALTH AND MEDICAL UNIVERSITY ERFURT GMBH
- MICROFLUIDICS INNOVATION CENTER
- ZURCHER HOCHSCHULE FUR ANGEWANDTE WISSENSCHAFTEN
- CARDIFF UNIVERSITY
Land(en)
Vergelijkbare projecten binnen EIC Pathfinder
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
PRInted Symbiotic Materials as a dynamic platform for Living Tissues productionPRISM-LT aims to develop a flexible bioprinting platform using hybrid living materials to enhance stem cell differentiation with engineered helper cells for biomedical and food applications. | EIC Pathfinder | € 2.805.403 | 2022 | Details |
building vascular networks and Blood-Brain-Barriers through a Biomimetic manufacturing Technology for the fabrication of Human tissues and ORgansTHOR aims to revolutionize tissue engineering by creating patient-specific, fully functional human tissues using bioinspired mini-robots, eliminating the need for organ transplants. | EIC Pathfinder | € 3.994.150 | 2023 | Details |
Supervised morphogenesis in gastruloidsThis project aims to develop advanced gastruloid technology to create larger, vascularized organ models that better mimic human physiology, reducing reliance on animal experiments. | EIC Pathfinder | € 3.337.725 | 2022 | Details |
High-throughput ultrasound-based volumetric 3D printing for tissue engineeringSONOCRAFT aims to revolutionize myocardial cell construct bioprinting by combining rapid volumetric printing with ultrasonic manipulation to create functional cardiac models for drug testing and disease research. | EIC Pathfinder | € 2.999.625 | 2025 | Details |
PRInted Symbiotic Materials as a dynamic platform for Living Tissues production
PRISM-LT aims to develop a flexible bioprinting platform using hybrid living materials to enhance stem cell differentiation with engineered helper cells for biomedical and food applications.
building vascular networks and Blood-Brain-Barriers through a Biomimetic manufacturing Technology for the fabrication of Human tissues and ORgans
THOR aims to revolutionize tissue engineering by creating patient-specific, fully functional human tissues using bioinspired mini-robots, eliminating the need for organ transplants.
Supervised morphogenesis in gastruloids
This project aims to develop advanced gastruloid technology to create larger, vascularized organ models that better mimic human physiology, reducing reliance on animal experiments.
High-throughput ultrasound-based volumetric 3D printing for tissue engineering
SONOCRAFT aims to revolutionize myocardial cell construct bioprinting by combining rapid volumetric printing with ultrasonic manipulation to create functional cardiac models for drug testing and disease research.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
3D-assembly of interactive microgels to grow in vitro vascularized, structured, and beating human cardiac tissues in high-throughputHEARTBEAT aims to create personalized, vascularized millimeter-scale heart tissues using innovative microgel assemblies to enhance stem cell interactions and mimic native environments. | ERC Consolid... | € 2.969.219 | 2022 | Details |
Protein-regulated artificial cell populations and tissuesThe PRO-ARTIS project aims to create interdependent artificial cell populations using a dynamic protein exchange platform to advance understanding of multicellular processes and integrate with living cells for biomedical applications. | ERC Advanced... | € 2.499.668 | 2024 | Details |
Holographic Optical Tweezing Bioprinting (HOTB): Towards precise manipulation of cells for artificial multi-scaled vascularized tissues/organ printing.The HOT-BIOPRINTING project aims to revolutionize tissue engineering by developing a holographic optical tweezing bioprinter for high-resolution, automated 3D bioprinting of complex, vascularized tissues. | ERC Consolid... | € 1.965.525 | 2024 | Details |
Plant based 4D biohybrid systemsThe 4D-PhytoHybrid project aims to create advanced photosynthetic biohybrid systems that integrate living plant cells with electronic materials to develop innovative hybrid technologies. | ERC Starting... | € 1.499.477 | 2022 | Details |
Engineering soft microdevices for the mechanical characterization and stimulation of microtissuesThis project aims to advance mechanobiology by developing soft robotic micro-devices to study and manipulate 3D tissue responses, enhancing understanding of cell behavior and potential cancer treatments. | ERC Advanced... | € 3.475.660 | 2025 | Details |
3D-assembly of interactive microgels to grow in vitro vascularized, structured, and beating human cardiac tissues in high-throughput
HEARTBEAT aims to create personalized, vascularized millimeter-scale heart tissues using innovative microgel assemblies to enhance stem cell interactions and mimic native environments.
Protein-regulated artificial cell populations and tissues
The PRO-ARTIS project aims to create interdependent artificial cell populations using a dynamic protein exchange platform to advance understanding of multicellular processes and integrate with living cells for biomedical applications.
Holographic Optical Tweezing Bioprinting (HOTB): Towards precise manipulation of cells for artificial multi-scaled vascularized tissues/organ printing.
The HOT-BIOPRINTING project aims to revolutionize tissue engineering by developing a holographic optical tweezing bioprinter for high-resolution, automated 3D bioprinting of complex, vascularized tissues.
Plant based 4D biohybrid systems
The 4D-PhytoHybrid project aims to create advanced photosynthetic biohybrid systems that integrate living plant cells with electronic materials to develop innovative hybrid technologies.
Engineering soft microdevices for the mechanical characterization and stimulation of microtissues
This project aims to advance mechanobiology by developing soft robotic micro-devices to study and manipulate 3D tissue responses, enhancing understanding of cell behavior and potential cancer treatments.